Single Cell LY49
Malassigne_Victor
11/15/2022
1 Library
2 import data
DE avec une résolition de 0.5, 11 clusters et 1976 gènes.
DE avec une résolition de 0.4, 9 clusters et 1448 gènes.
3 PCA UMAP cluster DE
DE all
## [1] "DE VV-B8R vs VV-B8R"
## [1] "DE VV-B8R vs Ly49p-CD8ab"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 0.000000e+00 4.619576 0.961 0.206 0.000000e+00
## Hist1h2ap 4.681708e-192 4.529325 0.743 0.186 7.180335e-188
## Gzma 4.852102e-186 4.025803 0.648 0.088 7.441669e-182
## Hist1h1b 8.368161e-231 3.962668 0.715 0.065 1.283425e-226
## S100a6 0.000000e+00 3.935983 0.990 0.702 0.000000e+00
## Hist1h2ae 4.525130e-175 3.912730 0.638 0.095 6.940192e-171
## Lgals3 0.000000e+00 3.243376 0.890 0.046 0.000000e+00
## Hist1h4d 6.901377e-170 2.958837 0.804 0.312 1.058464e-165
## Pclaf 5.664229e-238 2.946893 0.704 0.047 8.687228e-234
## Gzmb 9.895202e-272 2.901295 0.759 0.038 1.517627e-267
## Stmn1 3.325049e-213 2.895286 0.769 0.178 5.099627e-209
## Mki67 9.096165e-238 2.734321 0.694 0.034 1.395079e-233
## Birc5 1.647742e-228 2.569133 0.678 0.038 2.527141e-224
## Top2a 1.488952e-185 2.562916 0.633 0.070 2.283606e-181
## Hist1h1e 2.680599e-177 2.519989 0.903 0.511 4.111235e-173
## Itga4 0.000000e+00 2.467705 0.978 0.287 0.000000e+00
## Ube2c 6.291922e-206 2.398139 0.625 0.030 9.649921e-202
## Pycard 6.117077e-302 2.289124 0.993 0.716 9.381761e-298
## Id2 1.293362e-264 2.281628 0.916 0.299 1.983629e-260
## Hist1h3c 4.197325e-160 2.248199 0.506 0.021 6.437437e-156
## Hist1h2ab 4.916004e-149 2.230825 0.482 0.023 7.539675e-145
## Hist1h1d 9.305101e-227 2.138424 0.735 0.084 1.427123e-222
## Hist2h2ac 1.345101e-136 2.136971 0.628 0.157 2.062982e-132
## Anxa2 3.928532e-239 2.110863 0.911 0.417 6.025190e-235
## Lmnb1 8.512268e-211 1.987053 0.753 0.148 1.305526e-206
## Cks2 2.430831e-174 1.955351 0.726 0.187 3.728166e-170
## Hist1h3e 4.722629e-132 1.948860 0.577 0.120 7.243095e-128
## Dut 1.079216e-179 1.921129 0.816 0.331 1.655193e-175
## Tubb4b 6.281996e-94 1.886588 0.767 0.515 9.634697e-90
## Hist1h2bj 5.856668e-172 1.879793 0.542 0.026 8.982372e-168
## [1] "DE VV-B8R vs VV-Ly49p-CD8aa"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 0.000000e+00 4.219559 0.961 0.306 0.000000e+00
## Hist1h2ap 1.228415e-192 4.064150 0.743 0.210 1.884020e-188
## Hist1h1b 6.408032e-243 3.872954 0.715 0.079 9.827998e-239
## Hist1h2ae 2.370711e-179 3.723698 0.638 0.110 3.635959e-175
## Lgals1 0.000000e+00 3.670178 0.995 0.742 0.000000e+00
## Gzma 6.519866e-197 3.369775 0.648 0.088 9.999518e-193
## Lgals3 0.000000e+00 3.189893 0.890 0.063 0.000000e+00
## Pclaf 1.452589e-256 2.874426 0.704 0.051 2.227836e-252
## Gzmb 4.809335e-295 2.872528 0.759 0.042 7.376077e-291
## Cd8b1 0.000000e+00 2.784348 0.994 0.384 0.000000e+00
## Hist1h4d 9.654554e-149 2.746008 0.804 0.377 1.480719e-144
## Stmn1 6.038925e-225 2.736917 0.769 0.177 9.261900e-221
## Mki67 1.172889e-243 2.588801 0.694 0.055 1.798860e-239
## Birc5 7.900335e-243 2.487018 0.678 0.046 1.211674e-238
## Top2a 2.334266e-202 2.471154 0.633 0.067 3.580063e-198
## Ube2c 6.437515e-214 2.360444 0.625 0.044 9.873217e-210
## Pycard 0.000000e+00 2.287050 0.993 0.656 0.000000e+00
## Hist1h3c 2.190094e-172 2.189751 0.506 0.026 3.358948e-168
## Hist1h2ab 2.720391e-161 2.189251 0.482 0.027 4.172263e-157
## Id2 2.643928e-265 2.168865 0.916 0.335 4.054992e-261
## Vim 4.549715e-238 2.051718 0.970 0.691 6.977898e-234
## Hist2h2ac 5.981153e-124 2.032642 0.628 0.209 9.173294e-120
## Tuba1b 6.728130e-116 2.015278 0.724 0.406 1.031893e-111
## Cks2 5.270543e-209 2.004401 0.726 0.141 8.083431e-205
## Tubb4b 3.575517e-124 1.998469 0.767 0.412 5.483770e-120
## Hist1h1d 5.465504e-213 1.964022 0.735 0.127 8.382444e-209
## Lmnb1 8.684478e-229 1.962273 0.753 0.140 1.331938e-224
## Dut 5.529445e-197 1.931406 0.816 0.307 8.480511e-193
## Hist1h1e 2.321838e-115 1.912147 0.903 0.647 3.561004e-111
## 1500009L16Rik 1.807638e-304 1.887166 0.737 0.012 2.772374e-300
## [1] "DE VV-B8R vs Ly49p-CD8aa"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 1.212015e-260 4.471497 0.961 0.254 1.858867e-256
## Hist1h2ap 3.418588e-138 4.199375 0.743 0.208 5.243088e-134
## S100a6 3.036117e-260 4.028017 0.990 0.720 4.656493e-256
## Lgals1 3.379980e-263 3.976721 0.995 0.683 5.183876e-259
## Hist1h1b 1.679927e-168 3.865566 0.715 0.061 2.576504e-164
## Gzma 9.650857e-138 3.850053 0.648 0.081 1.480152e-133
## Hist1h2ae 8.976407e-124 3.793695 0.638 0.105 1.376712e-119
## Lgals3 6.990231e-249 3.212909 0.890 0.054 1.072092e-244
## Pclaf 8.517858e-172 2.902807 0.704 0.042 1.306384e-167
## Gzmb 7.343605e-189 2.852565 0.759 0.062 1.126289e-184
## Hist1h4d 1.040852e-122 2.821665 0.804 0.341 1.596354e-118
## Cd8b1 5.771777e-273 2.788721 0.994 0.433 8.852175e-269
## Stmn1 9.439935e-162 2.761989 0.769 0.172 1.447803e-157
## Mki67 3.069365e-168 2.678818 0.694 0.035 4.707485e-164
## Birc5 1.662413e-163 2.542212 0.678 0.036 2.549643e-159
## Top2a 4.601744e-133 2.512571 0.633 0.073 7.057695e-129
## Ube2c 2.168886e-147 2.435027 0.625 0.027 3.326420e-143
## Pycard 3.552098e-243 2.291194 0.993 0.657 5.447853e-239
## Hist1h2ab 6.819048e-103 2.199589 0.482 0.024 1.045837e-98
## Hist1h3c 5.050787e-107 2.191891 0.506 0.031 7.746392e-103
## Id2 3.098791e-198 2.172965 0.916 0.311 4.752616e-194
## Hist2h2ac 3.746119e-100 2.093237 0.628 0.165 5.745422e-96
## Vim 1.926021e-184 2.061320 0.970 0.680 2.953939e-180
## Hist1h1d 5.391800e-158 2.045600 0.735 0.105 8.269403e-154
## Hist1h1e 2.091200e-98 2.043079 0.903 0.621 3.207274e-94
## Cks2 1.428609e-142 2.003706 0.726 0.154 2.191058e-138
## Dut 6.889317e-150 1.951109 0.816 0.275 1.056615e-145
## Lmnb1 2.686380e-153 1.918751 0.753 0.160 4.120101e-149
## Tubb4b 4.045686e-82 1.907436 0.767 0.454 6.204869e-78
## Hist1h3e 1.414277e-94 1.900481 0.577 0.130 2.169076e-90
## [1] "DE VV-B8R vs VV-Ly49p-CD8ab"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 0.000000e+00 4.045198 0.961 0.294 0.000000e+00
## Hist1h2ap 3.843951e-249 3.968922 0.743 0.218 5.895467e-245
## Hist1h1b 0.000000e+00 3.836389 0.715 0.086 0.000000e+00
## Hist1h2ae 2.566387e-248 3.685974 0.638 0.111 3.936068e-244
## Lgals3 0.000000e+00 3.167568 0.890 0.060 0.000000e+00
## Gzma 1.519643e-252 3.105666 0.648 0.111 2.330677e-248
## Pclaf 0.000000e+00 2.811143 0.704 0.057 0.000000e+00
## Hist1h4d 2.379665e-196 2.766856 0.804 0.368 3.649693e-192
## Gzmb 0.000000e+00 2.703272 0.759 0.059 0.000000e+00
## Stmn1 6.869323e-267 2.547975 0.769 0.222 1.053548e-262
## Mki67 0.000000e+00 2.524503 0.694 0.057 0.000000e+00
## Itga4 0.000000e+00 2.478020 0.978 0.249 0.000000e+00
## Birc5 0.000000e+00 2.446553 0.678 0.056 0.000000e+00
## Top2a 1.278530e-280 2.380653 0.633 0.075 1.960882e-276
## Ube2c 5.100035e-308 2.317348 0.625 0.051 7.821923e-304
## Pycard 0.000000e+00 2.208507 0.993 0.738 0.000000e+00
## Hist1h1e 2.715839e-185 2.200504 0.903 0.579 4.165283e-181
## Hist1h2ab 7.457320e-242 2.164739 0.482 0.030 1.143729e-237
## Hist1h3c 7.270208e-262 2.158789 0.506 0.028 1.115032e-257
## Id2 0.000000e+00 2.073480 0.916 0.351 0.000000e+00
## Anxa2 4.253888e-304 2.064405 0.911 0.438 6.524188e-300
## Hist2h2ac 2.919819e-153 1.992480 0.628 0.217 4.478126e-149
## Hist1h1d 1.324166e-287 1.951460 0.735 0.134 2.030874e-283
## Cks2 1.043534e-254 1.938301 0.726 0.175 1.600468e-250
## Lmnb1 6.641436e-305 1.922931 0.753 0.144 1.018597e-300
## Dut 1.608271e-238 1.903916 0.816 0.334 2.466605e-234
## Tubb4b 9.313874e-125 1.888467 0.767 0.497 1.428469e-120
## 1500009L16Rik 0.000000e+00 1.852187 0.737 0.031 0.000000e+00
## Hist1h2bj 4.175113e-247 1.798836 0.542 0.053 6.403370e-243
## Hist1h3e 5.630487e-136 1.789017 0.577 0.201 8.635478e-132
## [1] "DE VV-B8R vs Naive"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a6 0.000000e+00 5.043378 0.990 0.550 0.000000e+00
## S100a4 0.000000e+00 4.831616 0.961 0.121 0.000000e+00
## Hist1h2ap 2.262413e-154 4.370503 0.743 0.256 3.469862e-150
## Lgals1 0.000000e+00 4.364198 0.995 0.633 0.000000e+00
## Gzma 1.210250e-179 4.018376 0.648 0.074 1.856160e-175
## Hist1h1b 1.664366e-209 3.960333 0.715 0.080 2.552637e-205
## Hist1h2ae 3.666433e-169 3.938657 0.638 0.082 5.623208e-165
## Lgals3 0.000000e+00 3.247915 0.890 0.041 0.000000e+00
## Stmn1 3.398002e-231 3.099892 0.769 0.102 5.211516e-227
## Pclaf 1.362493e-225 2.984915 0.704 0.042 2.089655e-221
## Gzmb 6.662872e-252 2.889356 0.759 0.041 1.021885e-247
## Hist1h4d 6.924978e-146 2.863691 0.804 0.328 1.062084e-141
## Mki67 3.573951e-222 2.779201 0.694 0.036 5.481368e-218
## Anxa2 0.000000e+00 2.749955 0.911 0.057 0.000000e+00
## Top2a 1.379259e-185 2.613230 0.633 0.048 2.115370e-181
## Birc5 2.925733e-220 2.602701 0.678 0.026 4.487196e-216
## Itgb1 2.666976e-303 2.547572 0.921 0.120 4.090341e-299
## Ube2c 1.974071e-195 2.439217 0.625 0.024 3.027632e-191
## Hist1h1e 7.090358e-142 2.277166 0.903 0.536 1.087448e-137
## Hist1h3c 3.657773e-147 2.260173 0.506 0.024 5.609926e-143
## Hist1h2ab 8.613779e-141 2.244971 0.482 0.019 1.321095e-136
## Pycard 4.218470e-284 2.229500 0.993 0.655 6.469868e-280
## Txn1 3.001470e-279 2.089301 0.993 0.649 4.603355e-275
## Hist2h2ac 5.966045e-114 2.064330 0.628 0.192 9.150123e-110
## Cks2 8.743572e-193 2.048757 0.726 0.116 1.341002e-188
## Itga4 1.963614e-274 2.045696 0.978 0.474 3.011595e-270
## Hist1h1d 2.658858e-193 2.040729 0.735 0.116 4.077891e-189
## Lmnb1 1.231064e-213 2.038269 0.753 0.111 1.888082e-209
## Id2 3.104566e-213 1.978046 0.916 0.380 4.761473e-209
## Tubb4b 7.521847e-106 1.957347 0.767 0.409 1.153626e-101
## [1] "DE VV-B8R vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Gzma 9.536349e-30 3.646931 0.648 0.131 1.462590e-25
## S100a4 2.295930e-61 3.262411 0.961 0.365 3.521267e-57
## S100a6 1.258797e-67 3.167273 0.990 0.737 1.930617e-63
## Hist1h2ap 3.348633e-29 3.131367 0.743 0.292 5.135798e-25
## Hist1h2ae 2.175454e-27 3.069130 0.638 0.124 3.336493e-23
## Lgals3 7.745229e-58 2.941249 0.890 0.124 1.187886e-53
## Hist1h1b 4.285285e-35 2.824108 0.715 0.095 6.572341e-31
## Gzmb 4.552796e-44 2.750233 0.759 0.073 6.982623e-40
## Pclaf 3.030608e-36 2.428410 0.704 0.066 4.648044e-32
## Hist1h4d 3.631550e-28 2.305766 0.804 0.380 5.569708e-24
## Anxa2 8.208830e-57 2.293979 0.911 0.270 1.258988e-52
## Birc5 2.409664e-34 2.234039 0.678 0.066 3.695701e-30
## Stmn1 1.291779e-33 2.159341 0.769 0.255 1.981201e-29
## Hist1h1e 3.079043e-35 2.153286 0.903 0.569 4.722328e-31
## Mki67 6.347852e-33 2.153231 0.694 0.095 9.735700e-29
## Ube2c 5.392693e-28 2.101077 0.625 0.095 8.270774e-24
## Hist1h3c 1.570670e-21 2.074037 0.506 0.066 2.408937e-17
## Top2a 5.177090e-26 1.935617 0.633 0.124 7.940103e-22
## Hist1h2ab 1.178353e-19 1.905029 0.482 0.058 1.807240e-15
## Itga4 1.354952e-56 1.857447 0.978 0.423 2.078090e-52
## Hist2h2ac 2.886997e-21 1.831744 0.628 0.219 4.427788e-17
## Tubb4b 4.428574e-21 1.771560 0.767 0.474 6.792103e-17
## 1500009L16Rik 2.241094e-40 1.745440 0.737 0.080 3.437166e-36
## Hist1h3e 4.764842e-21 1.703047 0.577 0.146 7.307838e-17
## Hist1h1d 1.400936e-31 1.687756 0.735 0.175 2.148615e-27
## Hist1h2bj 4.788324e-22 1.682267 0.542 0.095 7.343853e-18
## Id2 1.959397e-41 1.681628 0.916 0.453 3.005127e-37
## Cks2 3.413914e-28 1.660391 0.726 0.255 5.235919e-24
## Cks1b 2.568719e-32 1.633207 0.664 0.095 3.939645e-28
## Dut 1.140960e-32 1.628078 0.816 0.350 1.749890e-28
## [1] "DE Ly49p-CD8ab vs Ly49p-CD8ab"
## [1] "DE Ly49p-CD8ab vs VV-Ly49p-CD8aa"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Cd8b1 0.000000e+00 1.8682067 0.956 0.384 0.000000e+00
## Fos 1.969194e-214 1.5244674 0.934 0.636 3.020152e-210
## Dusp2 1.315582e-152 1.1294877 0.878 0.518 2.017708e-148
## Fosb 4.658644e-138 1.0454337 0.926 0.671 7.144962e-134
## Klf6 6.436125e-117 0.8989381 0.879 0.615 9.871085e-113
## Tnfaip3 6.666376e-125 0.8742924 0.666 0.261 1.022422e-120
## Zfp36 3.963887e-95 0.7710059 0.822 0.541 6.079413e-91
## Coq10b 3.471470e-119 0.7200856 0.695 0.289 5.324193e-115
## Nfkbia 4.181174e-70 0.5841423 0.797 0.512 6.412666e-66
## Klf4 6.958855e-57 0.5678207 0.406 0.150 1.067280e-52
## Ppp1r15a 3.633111e-62 0.5586849 0.712 0.431 5.572102e-58
## Rgs1 2.998597e-48 0.5236201 0.650 0.389 4.598949e-44
## Klrc2 3.158399e-58 -0.5781436 0.186 0.460 4.844037e-54
## Anxa2 7.417552e-57 -0.6151540 0.417 0.673 1.137630e-52
## Itga4 1.328944e-52 -0.7206676 0.287 0.547 2.038202e-48
## Klre1 4.566624e-84 -0.8533522 0.387 0.717 7.003831e-80
## Fcer1g 4.509538e-122 -1.0129007 0.062 0.462 6.916278e-118
## Klrk1 1.255610e-108 -1.1461701 0.228 0.632 1.925729e-104
## Ikzf2 7.994055e-159 -1.2099466 0.334 0.835 1.226048e-154
## [1] "DE Ly49p-CD8ab vs Ly49p-CD8aa"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Cd8b1 3.865140e-247 1.8725799 0.956 0.433 5.927965e-243
## Itga4 4.310005e-72 -0.9446485 0.287 0.644 6.610255e-68
## Fcer1g 1.691652e-105 -1.1094801 0.062 0.459 2.594487e-101
## Ikzf2 9.577276e-140 -1.3236079 0.334 0.854 1.468867e-135
## [1] "DE Ly49p-CD8ab vs VV-Ly49p-CD8ab"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 0.000000e+00 1.7551937 0.934 0.558 0.000000e+00
## Fosb 3.794425e-242 1.2865216 0.926 0.621 5.819510e-238
## Dusp2 1.204030e-224 1.2432066 0.878 0.505 1.846621e-220
## Dusp1 4.655635e-187 1.0836610 0.815 0.441 7.140347e-183
## Klf6 1.181774e-196 1.0689593 0.879 0.570 1.812487e-192
## Tnfaip3 1.157839e-184 0.9276171 0.666 0.241 1.775777e-180
## Zfp36 3.566316e-152 0.8805337 0.822 0.501 5.469659e-148
## Nfkbia 1.123317e-143 0.8197039 0.797 0.450 1.722831e-139
## Rgs1 1.770952e-117 0.7685442 0.650 0.303 2.716109e-113
## Coq10b 7.613556e-163 0.7464495 0.695 0.292 1.167691e-158
## Klf4 5.247034e-112 0.6456116 0.406 0.105 8.047376e-108
## Ppp1r15a 3.056440e-85 0.5985544 0.712 0.449 4.687662e-81
## [1] "DE Ly49p-CD8ab vs Naive"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 6.865350e-281 1.9334619 0.951 0.624 1.052939e-276
## Xcl1 7.688452e-225 1.4102403 0.655 0.021 1.179178e-220
## Il2rb 3.969816e-241 1.4036538 0.923 0.423 6.088507e-237
## Klra7 4.337467e-146 1.1466229 0.501 0.033 6.652373e-142
## Ccl4 1.018280e-109 1.1057526 0.390 0.021 1.561736e-105
## Hopx 3.710104e-167 1.0052186 0.761 0.203 5.690187e-163
## Ahnak 1.656140e-115 0.9891231 0.749 0.321 2.540022e-111
## Ms4a4c 3.200951e-136 0.9626732 0.712 0.212 4.909299e-132
## Klre1 4.189817e-110 0.9622405 0.387 0.019 6.425922e-106
## Gzmm 1.154011e-109 0.9609110 0.374 0.012 1.769907e-105
## Eomes 7.011068e-144 0.9040356 0.556 0.073 1.075287e-139
## Klra6 1.088923e-133 0.8760049 0.441 0.015 1.670081e-129
## 1700025G04Rik 4.226943e-161 0.8308433 0.533 0.031 6.482862e-157
## Cxcr3 8.054869e-164 0.8276666 0.533 0.027 1.235375e-159
## Cd44 6.158541e-146 0.7686513 0.491 0.027 9.445355e-142
## Ikzf2 1.425617e-66 0.7642501 0.334 0.056 2.186468e-62
## Il18r1 4.810513e-110 0.7605472 0.624 0.178 7.377883e-106
## Itgb1 3.547920e-105 0.7566061 0.544 0.120 5.441445e-101
## Samd3 2.702255e-146 0.7358999 0.465 0.011 4.144449e-142
## Bcl2 4.972640e-84 0.7031275 0.875 0.541 7.626538e-80
## Rgs1 2.494577e-74 0.6948788 0.650 0.281 3.825932e-70
## Zyx 7.558160e-84 0.6802123 0.772 0.386 1.159195e-79
## Ctsw 4.855918e-88 0.6691398 0.910 0.624 7.447521e-84
## Rhob 1.248523e-68 0.6489186 0.553 0.209 1.914860e-64
## Plek 5.498634e-110 0.6461709 0.391 0.021 8.433255e-106
## Anxa2 7.776734e-94 0.6390917 0.417 0.057 1.192718e-89
## Pde2a 4.416261e-95 0.6349185 0.592 0.181 6.773219e-91
## Cst7 3.103748e-82 0.6327936 0.699 0.316 4.760218e-78
## Ifngr1 9.744876e-79 0.6320498 0.764 0.370 1.494572e-74
## Id3 7.624989e-56 0.6293722 0.535 0.238 1.169445e-51
## [1] "DE Ly49p-CD8ab vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Klra7 1.933474e-18 1.0279368 0.501 0.109 2.965369e-14
## Klra6 3.228370e-21 0.8728633 0.441 0.007 4.951352e-17
## [1] "DE VV-Ly49p-CD8aa vs VV-Ly49p-CD8aa"
## [1] "DE VV-Ly49p-CD8aa vs Ly49p-CD8aa"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Rgs2 3.231486e-44 -0.5025670 0.173 0.429 4.956131e-40
## Coq10b 2.632200e-69 -0.6793955 0.289 0.616 4.037005e-65
## Nfkbia 7.490353e-72 -0.8540684 0.512 0.791 1.148795e-67
## Zfp36 2.689537e-84 -0.9305747 0.541 0.817 4.124943e-80
## Rgs1 6.756676e-69 -0.9458827 0.389 0.703 1.036271e-64
## Klf6 2.132433e-120 -1.0820722 0.615 0.895 3.270513e-116
## Tnfaip3 1.244312e-124 -1.0830086 0.261 0.705 1.908401e-120
## Dusp2 6.676812e-102 -1.0963681 0.518 0.832 1.024023e-97
## Fosb 9.443916e-133 -1.2057930 0.671 0.926 1.448413e-128
## Fos 3.013171e-193 -1.7322322 0.636 0.948 4.621300e-189
## [1] "DE VV-Ly49p-CD8aa vs VV-Ly49p-CD8ab"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ikzf2 1.110642e-305 1.4589370 0.835 0.268 1.703392e-301
## Fcer1g 1.614270e-224 1.0642954 0.462 0.048 2.475806e-220
## Klrk1 1.487680e-103 0.9546363 0.632 0.323 2.281654e-99
## Itga4 4.307503e-93 0.7309825 0.547 0.249 6.606418e-89
## Fcgrt 2.388567e-80 -0.5316781 0.100 0.371 3.663346e-76
## Cd8b1 0.000000e+00 -1.9956289 0.384 0.977 0.000000e+00
## [1] "DE VV-Ly49p-CD8aa vs Naive"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 0.000000e+00 2.3078411 0.961 0.624 0.000000e+00
## Klra7 3.043583e-267 2.1034292 0.725 0.033 4.667943e-263
## Ikzf2 0.000000e+00 1.9741968 0.835 0.056 0.000000e+00
## Klrk1 5.701815e-218 1.8883299 0.632 0.031 8.744873e-214
## Klre1 6.159132e-270 1.8155927 0.717 0.019 9.446261e-266
## Xcl1 1.464979e-280 1.7152019 0.743 0.021 2.246839e-276
## Il2rb 0.000000e+00 1.6596087 0.957 0.423 0.000000e+00
## Klra6 4.035568e-220 1.4964806 0.621 0.015 6.189351e-216
## S100a6 4.524085e-126 1.4918842 0.807 0.550 6.938589e-122
## Ahnak 3.532739e-188 1.2877073 0.832 0.321 5.418162e-184
## Anxa2 2.345743e-217 1.2542458 0.673 0.057 3.597666e-213
## Fcer1g 7.498473e-149 1.1513796 0.462 0.009 1.150041e-144
## Hopx 4.700167e-180 1.1280340 0.751 0.203 7.208646e-176
## Klra1 9.352746e-82 1.0566778 0.290 0.011 1.434431e-77
## Ms4a4c 5.775777e-138 1.0482392 0.692 0.212 8.858309e-134
## Itgb1 3.118501e-154 1.0294466 0.633 0.120 4.782845e-150
## Pglyrp1 2.471153e-166 1.0244577 0.613 0.086 3.790008e-162
## Cd7 1.220636e-126 0.9829528 0.710 0.237 1.872090e-122
## Cd160 4.816067e-148 0.9761367 0.585 0.092 7.386402e-144
## Cxcr3 5.313831e-202 0.9715222 0.603 0.027 8.149823e-198
## Il18r1 6.159778e-139 0.9670166 0.661 0.178 9.447251e-135
## Eomes 5.104082e-149 0.9541438 0.555 0.073 7.828131e-145
## Samd3 1.490089e-186 0.9133206 0.547 0.011 2.285349e-182
## Klrc2 2.081975e-150 0.8949474 0.460 0.007 3.193125e-146
## Bcl2 3.917255e-109 0.8582931 0.886 0.541 6.007894e-105
## 1700025G04Rik 7.799853e-156 0.8366689 0.512 0.031 1.196263e-151
## Ctsw 4.173766e-133 0.8340960 0.930 0.624 6.401305e-129
## Zyx 1.044408e-115 0.8261338 0.804 0.386 1.601809e-111
## Efhd2 8.729657e-120 0.7684688 0.622 0.166 1.338868e-115
## Plek 4.467703e-131 0.7613326 0.438 0.021 6.852116e-127
## [1] "DE VV-Ly49p-CD8aa vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Klra7 1.456224e-40 1.9847431 0.725 0.109 2.233411e-36
## Ikzf2 7.935941e-48 1.7366748 0.835 0.146 1.217135e-43
## Klre1 9.792458e-35 1.5084408 0.717 0.153 1.501869e-30
## Klra6 1.638193e-35 1.4933389 0.621 0.007 2.512497e-31
## Klrk1 6.742612e-21 1.2127111 0.632 0.204 1.034114e-16
## Fcer1g 3.304366e-21 1.1115853 0.462 0.029 5.067907e-17
## Klra1 3.699939e-12 1.0553809 0.290 0.015 5.674596e-08
## Xcl1 2.884917e-14 0.8119993 0.743 0.409 4.424598e-10
## Anxa2 1.161873e-18 0.7982696 0.673 0.270 1.781965e-14
## Klrc2 1.504677e-13 0.6452669 0.460 0.131 2.307722e-09
## Cd160 2.046794e-12 0.6415188 0.585 0.277 3.139168e-08
## Cd7 1.097120e-11 0.6146275 0.710 0.416 1.682653e-07
## Cd6 6.999501e-12 -0.5180418 0.342 0.599 1.073513e-07
## Inpp4b 1.069359e-31 -0.5373334 0.057 0.336 1.640075e-27
## Fam169b 1.570500e-20 -0.6176924 0.230 0.569 2.408676e-16
## Coq10b 8.463801e-20 -0.6455538 0.289 0.613 1.298093e-15
## Tnfaip3 5.340595e-28 -0.9031988 0.261 0.650 8.190871e-24
## Fos 2.769539e-21 -1.0090485 0.636 0.891 4.247642e-17
## Cd8b1 2.255039e-87 -2.2873833 0.384 0.971 3.458553e-83
## [1] "DE Ly49p-CD8aa vs Ly49p-CD8aa"
## [1] "DE Ly49p-CD8aa vs VV-Ly49p-CD8ab"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 3.116545e-270 1.9629586 0.948 0.558 4.779845e-266
## Ikzf2 3.840253e-246 1.5725983 0.854 0.268 5.889796e-242
## Fosb 1.511150e-208 1.4468809 0.926 0.621 2.317651e-204
## Dusp1 1.507465e-148 1.2887586 0.803 0.441 2.311999e-144
## Klf6 8.683853e-181 1.2520933 0.895 0.570 1.331842e-176
## Dusp2 1.744779e-142 1.2100871 0.832 0.505 2.675968e-138
## Rgs1 1.875790e-133 1.1908068 0.703 0.303 2.876899e-129
## Fcer1g 1.055434e-188 1.1608748 0.459 0.048 1.618719e-184
## Tnfaip3 4.391400e-174 1.1363333 0.705 0.241 6.735091e-170
## Nfkbia 1.650966e-127 1.0896299 0.791 0.450 2.532086e-123
## Zfp36 3.432653e-124 1.0401025 0.817 0.501 5.264660e-120
## Itga4 1.398249e-112 0.9549634 0.644 0.249 2.144494e-108
## Coq10b 3.297038e-89 0.7057594 0.616 0.292 5.056667e-85
## Klf4 3.530352e-89 0.7007384 0.398 0.105 5.414501e-85
## Id3 3.449463e-57 0.6757459 0.643 0.373 5.290442e-53
## Gem 3.670647e-103 0.6121413 0.439 0.111 5.629671e-99
## Rgs2 7.522823e-72 0.5577329 0.429 0.148 1.153775e-67
## Ms4a4c 5.558733e-58 -0.5772397 0.523 0.806 8.525428e-54
## Plac8 2.491182e-42 -0.5915898 0.377 0.643 3.820726e-38
## Fcgrt 1.200521e-74 -0.6365490 0.039 0.371 1.841240e-70
## Gzmm 3.735394e-65 -0.8958566 0.133 0.466 5.728973e-61
## Cd8b1 0.000000e+00 -2.0000021 0.433 0.977 0.000000e+00
## [1] "DE Ly49p-CD8aa vs Naive"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ikzf2 8.811906e-280 2.0878581 0.854 0.056 1.351482e-275
## Xcl1 1.943265e-228 1.9203068 0.705 0.021 2.980386e-224
## Ctla2a 2.556388e-189 1.8171538 0.931 0.624 3.920732e-185
## Il2rb 3.441167e-251 1.7369790 0.960 0.423 5.277718e-247
## Klra7 1.906482e-182 1.6507089 0.615 0.033 2.923971e-178
## Klrk1 2.294893e-120 1.5619435 0.454 0.031 3.519677e-116
## Klre1 2.310877e-141 1.2509530 0.490 0.019 3.544192e-137
## Fcer1g 3.488915e-136 1.2479590 0.459 0.009 5.350948e-132
## Klra6 3.983623e-156 1.1736764 0.522 0.015 6.109683e-152
## Anxa2 2.630350e-163 1.1414116 0.619 0.057 4.034168e-159
## Ahnak 3.396615e-110 1.1354118 0.760 0.321 5.209389e-106
## Rgs1 6.347301e-92 1.1171414 0.703 0.281 9.734856e-88
## Cd160 1.682110e-132 1.1156606 0.596 0.092 2.579852e-128
## Cd7 4.130022e-87 1.0655433 0.662 0.237 6.334215e-83
## Hopx 9.102420e-133 1.0502277 0.724 0.203 1.396038e-128
## Klra1 3.121493e-88 0.9557258 0.326 0.011 4.787434e-84
## Pglyrp1 7.590536e-124 0.9059146 0.571 0.086 1.164160e-119
## Id3 1.693402e-82 0.8977779 0.643 0.238 2.597170e-78
## Rhob 5.033486e-79 0.8746276 0.610 0.209 7.719858e-75
## Cxcr3 1.754171e-146 0.8332154 0.523 0.027 2.690373e-142
## Ifngr1 2.064233e-86 0.8284449 0.785 0.370 3.165914e-82
## Zyx 1.810441e-77 0.7704631 0.771 0.386 2.776673e-73
## Bcl2 6.566532e-65 0.7644504 0.851 0.541 1.007109e-60
## Ctsw 9.464339e-86 0.7628502 0.918 0.624 1.451546e-81
## 1700025G04Rik 4.050208e-119 0.7395054 0.459 0.031 6.211804e-115
## Gem 6.373274e-117 0.7389347 0.439 0.024 9.774690e-113
## Efhd2 1.052053e-80 0.7158627 0.569 0.166 1.613534e-76
## Eomes 1.089313e-77 0.7061621 0.416 0.073 1.670679e-73
## Samd3 8.202394e-125 0.7008413 0.432 0.011 1.258001e-120
## Cd44 5.975135e-116 0.6986325 0.442 0.027 9.164064e-112
## [1] "DE Ly49p-CD8aa vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ikzf2 2.123159e-48 1.8503361 0.854 0.146 3.256289e-44
## Klra7 1.713660e-27 1.5320228 0.615 0.109 2.628241e-23
## Fcer1g 2.312840e-20 1.2081647 0.459 0.029 3.547203e-16
## Klra6 3.016884e-26 1.1705348 0.522 0.007 4.626995e-22
## Xcl1 5.307908e-13 1.0171042 0.705 0.409 8.140738e-09
## Klra1 9.801836e-14 0.9544290 0.326 0.015 1.503308e-09
## Klre1 6.069672e-14 0.9438011 0.490 0.153 9.309056e-10
## Klrk1 8.789652e-09 0.8863248 0.454 0.204 1.348069e-04
## Cd160 2.382309e-13 0.7810428 0.596 0.277 3.653748e-09
## Anxa2 1.460770e-13 0.6854355 0.619 0.270 2.240382e-09
## Klhdc2 1.167690e-11 0.5952371 0.478 0.175 1.790886e-07
## Cd6 1.850028e-11 -0.5220472 0.331 0.599 2.837388e-07
## Inpp4b 3.211041e-23 -0.5270960 0.064 0.336 4.924773e-19
## Fam169b 1.134364e-20 -0.6497865 0.217 0.569 1.739773e-16
## Gzmm 2.297732e-17 -0.8009744 0.133 0.416 3.524031e-13
## Cd8b1 1.664777e-77 -2.2917565 0.433 0.971 2.553269e-73
## [1] "DE VV-Ly49p-CD8ab vs VV-Ly49p-CD8ab"
## [1] "DE VV-Ly49p-CD8ab vs Naive"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 0.000000e+00 2.1815591 0.965 0.624 0.000000e+00
## S100a6 7.444558e-191 1.8770076 0.826 0.550 1.141772e-186
## Klra7 1.329269e-197 1.4081769 0.565 0.033 2.038701e-193
## Klre1 9.101272e-180 1.2714795 0.513 0.019 1.395862e-175
## Il2rb 7.001781e-287 1.2667761 0.913 0.423 1.073863e-282
## Xcl1 1.495133e-251 1.2611915 0.647 0.021 2.293086e-247
## Ms4a4c 1.356065e-240 1.2287884 0.806 0.212 2.079796e-236
## Gzmm 3.628305e-160 1.2215177 0.466 0.012 5.564731e-156
## Ahnak 3.413500e-214 1.2031506 0.828 0.321 5.235285e-210
## Hopx 1.445667e-235 1.1087193 0.795 0.203 2.217219e-231
## Klra6 7.810974e-180 1.0612765 0.509 0.015 1.197969e-175
## Il18r1 1.771544e-205 1.0471457 0.732 0.178 2.717017e-201
## Eomes 7.013564e-212 1.0327932 0.634 0.073 1.075670e-207
## Itgb1 8.484922e-177 0.9736557 0.639 0.120 1.301333e-172
## Klrk1 1.147298e-86 0.9336936 0.323 0.031 1.759611e-82
## Cxcr3 2.082458e-222 0.9272896 0.600 0.027 3.193866e-218
## Samd3 8.966313e-207 0.9078114 0.552 0.011 1.375163e-202
## Plek 1.435539e-196 0.8988987 0.546 0.021 2.201687e-192
## 1700025G04Rik 6.082854e-193 0.8660899 0.553 0.031 9.329273e-189
## Bcl2 4.401871e-133 0.8086961 0.892 0.541 6.751149e-129
## Pglyrp1 2.662526e-155 0.7826244 0.562 0.086 4.083516e-151
## Ctsw 7.548381e-156 0.7822622 0.929 0.624 1.157695e-151
## Cd44 1.090396e-165 0.7270016 0.496 0.027 1.672340e-161
## Zyx 4.587696e-129 0.7198200 0.817 0.386 7.036149e-125
## Pde2a 1.018728e-130 0.6930824 0.619 0.181 1.562423e-126
## Anxa2 2.952087e-115 0.6855498 0.438 0.057 4.527617e-111
## Ccl4 8.874265e-76 0.6854276 0.282 0.021 1.361046e-71
## Cst7 6.555324e-117 0.6800889 0.723 0.316 1.005390e-112
## Ctla2b 2.346082e-121 0.6453240 0.404 0.027 3.598186e-117
## Tm6sf1 5.389738e-116 0.6396177 0.533 0.133 8.266241e-112
## [1] "DE VV-Ly49p-CD8ab vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Klra7 2.849294e-24 1.2894908 0.565 0.109 4.369962e-20
## Klra6 1.120920e-26 1.0581348 0.509 0.007 1.719155e-22
## Klre1 3.049518e-16 0.9643276 0.513 0.153 4.677045e-12
## Klf4 2.138027e-22 -0.5893974 0.105 0.372 3.279092e-18
## Coq10b 1.141567e-21 -0.6719177 0.292 0.613 1.750821e-17
## Rgs1 7.288248e-15 -0.7160311 0.303 0.555 1.117799e-10
## Zfp36 3.833668e-18 -0.8111317 0.501 0.752 5.879697e-14
## Dusp1 5.826678e-21 -0.8894706 0.441 0.730 8.936377e-17
## Tnfaip3 3.193030e-34 -0.9565235 0.241 0.650 4.897151e-30
## Klf6 1.874644e-24 -1.0197226 0.570 0.832 2.875142e-20
## Fosb 1.127212e-27 -1.0715086 0.621 0.883 1.728805e-23
## Fos 1.404702e-32 -1.2397749 0.558 0.891 2.154391e-28
## [1] "DE Naive vs Naive"
## [1] "DE Naive vs Ly49n"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Lef1 2.471631e-31 1.0591770 0.904 0.642 3.790740e-27
## Ccr9 1.250968e-22 0.9732148 0.481 0.029 1.918610e-18
## Dapl1 3.855302e-10 0.8897617 0.574 0.299 5.912876e-06
## Igfbp4 5.883636e-14 0.7558162 0.353 0.036 9.023732e-10
## Rgcc 3.784767e-16 0.6826695 0.554 0.175 5.804697e-12
## Itm2a 4.130415e-38 -0.5045329 0.044 0.350 6.334817e-34
## Cst7 8.694753e-12 -0.5072386 0.316 0.591 1.333514e-07
## Txndc5 6.529644e-33 -0.5318552 0.067 0.387 1.001451e-28
## Itgal 1.693128e-13 -0.5399739 0.346 0.642 2.596751e-09
## Ifngr1 3.807438e-12 -0.5491860 0.370 0.664 5.839468e-08
## 1700025G04Rik 1.522417e-38 -0.5560224 0.031 0.307 2.334930e-34
## Rnf138 3.140343e-16 -0.5850871 0.346 0.679 4.816345e-12
## Ctsw 4.942969e-14 -0.5869655 0.624 0.891 7.581032e-10
## Gng2 2.037402e-21 -0.5976162 0.156 0.482 3.124764e-17
## Samd3 1.263715e-80 -0.6034550 0.011 0.387 1.938160e-76
## Pglyrp1 2.869777e-33 -0.6148231 0.086 0.438 4.401377e-29
## Rgs1 2.672147e-13 -0.6423657 0.281 0.555 4.098271e-09
## Ccl4 2.019656e-54 -0.6724148 0.021 0.336 3.097547e-50
## Zyx 2.609302e-18 -0.6801553 0.386 0.737 4.001886e-14
## Prr13 4.154747e-27 -0.7285035 0.177 0.562 6.372135e-23
## Ms4a4c 5.642535e-20 -0.7495525 0.212 0.547 8.653956e-16
## Il18r1 6.216047e-26 -0.8111235 0.178 0.540 9.533551e-22
## Cd44 1.166508e-81 -0.8285565 0.027 0.474 1.789073e-77
## Eomes 4.461304e-45 -0.8657538 0.073 0.467 6.842302e-41
## Xcl1 3.707202e-71 -0.9032026 0.021 0.409 5.685735e-67
## Cxcr3 5.658568e-106 -0.9087110 0.027 0.569 8.678546e-102
## Il2rb 6.741661e-41 -1.0694320 0.423 0.876 1.033969e-36
## Hopx 9.142942e-52 -1.0769813 0.203 0.759 1.402253e-47
## Gzmm 1.237476e-87 -1.1266355 0.012 0.416 1.897917e-83
## Ahnak 1.545910e-31 -1.1485674 0.321 0.745 2.370961e-27
## [1] "DE Ly49n vs Ly49n"## [1] "DE 0 vs 0"
## [1] "DE 0 vs 1"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Gem 1.096056e-110 -0.5093410 0.114 0.402 1.681021e-106
## Ppp1r15a 3.288775e-103 -0.6045273 0.453 0.719 5.043995e-99
## Klf4 9.495697e-129 -0.6907268 0.119 0.432 1.456355e-124
## Coq10b 1.927529e-188 -0.7631465 0.302 0.700 2.956251e-184
## Rgs1 4.753369e-179 -0.9823089 0.315 0.700 7.290242e-175
## Nfkbia 3.332982e-208 -0.9942741 0.462 0.823 5.111794e-204
## Zfp36 5.120523e-224 -1.0115130 0.507 0.854 7.853347e-220
## Tnfaip3 4.944897e-240 -1.0254733 0.248 0.704 7.583988e-236
## Klf6 8.356150e-272 -1.1577549 0.582 0.900 1.281583e-267
## Dusp1 8.046093e-271 -1.2509733 0.449 0.848 1.234029e-266
## Dusp2 2.410210e-276 -1.2817832 0.526 0.880 3.696539e-272
## Fosb 0.000000e+00 -1.4213600 0.635 0.949 0.000000e+00
## Fos 0.000000e+00 -1.8920211 0.568 0.965 0.000000e+00
## [1] "DE 0 vs 2"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Cd8b1 5.225893e-210 1.1742290 0.902 0.515 8.014952e-206
## Klrc2 3.567182e-85 -0.5833325 0.216 0.515 5.470987e-81
## Itga4 2.101050e-71 -0.6518190 0.238 0.502 3.222380e-67
## Klre1 2.334422e-82 -0.6969061 0.505 0.764 3.580303e-78
## Fcer1g 2.880184e-166 -0.8676528 0.056 0.413 4.417339e-162
## Ikzf2 2.254799e-211 -1.2150370 0.292 0.770 3.458185e-207
## Klrk1 1.050637e-147 -1.2304076 0.302 0.675 1.611362e-143
## [1] "DE 0 vs 3"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 0.000000e+00 2.1518805 0.977 0.620 0.000000e+00
## S100a6 1.131190e-188 1.6297337 0.823 0.541 1.734907e-184
## Klra7 3.154131e-204 1.3482756 0.577 0.040 4.837491e-200
## Il2rb 2.242902e-301 1.2778170 0.923 0.429 3.439939e-297
## Xcl1 1.279183e-277 1.2431590 0.679 0.023 1.961883e-273
## Ms4a4c 1.192591e-251 1.2079022 0.824 0.222 1.829077e-247
## Klre1 4.035515e-178 1.2016820 0.505 0.022 6.189269e-174
## Gzmm 9.256616e-164 1.1874478 0.468 0.015 1.419687e-159
## Ahnak 1.374485e-215 1.1516458 0.832 0.322 2.108048e-211
## Hopx 1.035849e-238 1.0798403 0.804 0.210 1.588681e-234
## Klra6 1.985985e-179 1.0347696 0.513 0.025 3.045905e-175
## Il18r1 5.087309e-205 1.0067582 0.730 0.182 7.802406e-201
## Eomes 4.836787e-207 0.9879420 0.632 0.081 7.418180e-203
## Itgb1 4.661053e-175 0.9543145 0.642 0.131 7.148658e-171
## Cxcr3 1.399494e-228 0.9196612 0.615 0.036 2.146404e-224
## Samd3 2.580214e-219 0.8943361 0.577 0.019 3.957275e-215
## 1700025G04Rik 1.666591e-207 0.8767346 0.576 0.033 2.556050e-203
## Plek 4.818116e-192 0.8606318 0.534 0.024 7.389545e-188
## Bcl2 8.121702e-138 0.7921585 0.911 0.553 1.245625e-133
## Klrk1 1.075212e-78 0.7814689 0.302 0.034 1.649052e-74
## Pglyrp1 1.164933e-157 0.7493365 0.567 0.090 1.786658e-153
## Ctsw 3.897578e-147 0.7396972 0.936 0.634 5.977716e-143
## Cd44 2.781044e-173 0.7324260 0.507 0.030 4.265287e-169
## Pde2a 4.610816e-137 0.6971838 0.633 0.188 7.071608e-133
## Zyx 1.511095e-126 0.6969237 0.818 0.393 2.317567e-122
## Cst7 3.051243e-119 0.6747050 0.734 0.327 4.679692e-115
## Itm2a 4.142092e-115 0.6479349 0.413 0.048 6.352727e-111
## Anxa2 3.450824e-113 0.6347111 0.433 0.060 5.292529e-109
## Ctla2b 2.721364e-119 0.6203675 0.396 0.030 4.173756e-115
## Tm6sf1 4.416332e-114 0.6162509 0.531 0.137 6.773328e-110
## [1] "DE 0 vs 4"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Sell 1.552392e-245 1.6541538 0.967 0.246 2.380904e-241
## Bcl2 4.384676e-231 1.6485993 0.911 0.192 6.724778e-227
## Il7r 2.214061e-159 1.4654026 0.914 0.397 3.395706e-155
## Satb1 5.118353e-189 1.3193430 0.882 0.243 7.850018e-185
## Ms4a4c 7.058915e-175 1.3082688 0.824 0.175 1.082626e-170
## Rgs10 7.206769e-188 1.2910214 0.898 0.269 1.105302e-183
## Txk 1.461396e-143 1.0873430 0.893 0.405 2.241342e-139
## Xcl1 1.831078e-130 1.0296793 0.679 0.093 2.808324e-126
## Jun 3.604156e-104 0.9675829 0.890 0.474 5.527694e-100
## Nsg2 1.954450e-127 0.9154508 0.690 0.123 2.997540e-123
## Tcf7 1.638556e-106 0.8639339 0.923 0.466 2.513053e-102
## Klra7 1.011150e-86 0.8393852 0.577 0.096 1.550800e-82
## Rps27rt 2.608093e-112 0.8035192 0.965 0.687 4.000032e-108
## Rhob 7.010847e-82 0.7738323 0.495 0.063 1.075254e-77
## Klra6 7.149028e-75 0.7711203 0.513 0.085 1.096446e-70
## Pde2a 7.483101e-98 0.7618058 0.633 0.139 1.147683e-93
## Smad7 1.194325e-77 0.7254208 0.797 0.419 1.831737e-73
## Ssh2 1.897217e-77 0.7110053 0.751 0.353 2.909762e-73
## Lef1 1.312254e-75 0.7093290 0.739 0.345 2.012604e-71
## Snhg8 2.222135e-83 0.7047916 0.893 0.600 3.408089e-79
## Foxp1 5.435819e-73 0.6982377 0.804 0.446 8.336916e-69
## Samd3 9.155994e-82 0.6860396 0.577 0.135 1.404255e-77
## 1700025G04Rik 1.076378e-79 0.6822791 0.576 0.146 1.650841e-75
## Rapgef6 2.198782e-71 0.6745891 0.820 0.463 3.372272e-67
## Txnip 9.245680e-66 0.6503374 0.825 0.465 1.418010e-61
## Btg1 1.558582e-73 0.6375506 0.994 0.734 2.390397e-69
## Pdcd4 1.128773e-70 0.6368670 0.954 0.690 1.731199e-66
## Snhg12 7.709888e-68 0.6275270 0.602 0.205 1.182466e-63
## Eif4a2 4.015681e-69 0.6236735 0.814 0.498 6.158851e-65
## Zbtb20 7.010940e-55 0.6193516 0.427 0.091 1.075268e-50
## [1] "DE 0 vs 5"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Il7r 4.987728e-160 2.417999 0.914 0.056 7.649678e-156
## Btg1 9.181494e-171 2.217455 0.994 0.300 1.408166e-166
## Sell 2.844931e-183 2.187537 0.967 0.029 4.363270e-179
## Bcl2 1.627060e-165 1.996836 0.911 0.021 2.495422e-161
## Pdcd4 6.016984e-162 1.853713 0.954 0.185 9.228248e-158
## Jun 8.558073e-134 1.845488 0.890 0.168 1.312552e-129
## Gas5 2.117571e-165 1.810904 0.996 0.671 3.247719e-161
## Rgs10 1.600268e-156 1.766471 0.898 0.053 2.454332e-152
## Satb1 1.009520e-152 1.736804 0.882 0.047 1.548300e-148
## Tcf7 1.800992e-151 1.723407 0.923 0.097 2.762181e-147
## Txk 1.357297e-146 1.720369 0.893 0.106 2.081686e-142
## Rps27rt 1.180644e-153 1.595770 0.965 0.344 1.810754e-149
## Ms4a4c 6.387914e-131 1.591950 0.824 0.056 9.797143e-127
## Ltb 8.825464e-122 1.522693 0.977 0.432 1.353561e-117
## Klra7 1.052221e-74 1.415780 0.577 0.009 1.613792e-70
## Ccnd2 1.757340e-115 1.412995 0.891 0.291 2.695232e-111
## Ccl5 2.095815e-87 1.323753 0.996 0.685 3.214351e-83
## Grcc10 5.160242e-118 1.300325 0.959 0.497 7.914263e-114
## Rapgef6 3.898537e-112 1.298791 0.820 0.171 5.979186e-108
## Txnip 1.066305e-104 1.283653 0.825 0.197 1.635391e-100
## Xcl1 2.327363e-95 1.236391 0.679 0.018 3.569476e-91
## Foxp1 3.772313e-102 1.231139 0.804 0.182 5.785596e-98
## Lars2 1.005148e-108 1.224693 0.984 0.659 1.541596e-104
## Ablim1 2.732260e-107 1.212615 0.935 0.468 4.190468e-103
## Smad7 7.328161e-99 1.196562 0.797 0.179 1.123920e-94
## Hcst 2.485622e-105 1.166681 0.996 0.741 3.812198e-101
## 2410006H16Rik 1.056210e-83 1.147635 0.851 0.385 1.619909e-79
## Junb 1.330289e-83 1.144535 0.877 0.353 2.040264e-79
## Zfp36l2 1.250710e-84 1.144424 0.886 0.462 1.918213e-80
## Nsg2 5.756195e-102 1.138365 0.690 0.009 8.828277e-98
## [1] "DE 0 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Cd8b1 2.741440e-95 1.6357056 0.902 0.562 4.204546e-91
## Gzmm 6.875954e-44 1.1713427 0.468 0.028 1.054565e-39
## Ms4a4c 2.448449e-64 0.9758127 0.824 0.278 3.755186e-60
## Thy1 1.317129e-55 0.8364123 0.938 0.611 2.020081e-51
## Il18r1 4.458901e-40 0.7009080 0.730 0.281 6.838616e-36
## Plac8 1.241455e-30 0.6940703 0.642 0.257 1.904019e-26
## Klk8 4.833201e-37 0.6860408 0.796 0.424 7.412681e-33
## Plek 3.838260e-37 0.6707491 0.534 0.118 5.886739e-33
## Ccr7 1.197948e-32 0.6328395 0.515 0.132 1.837293e-28
## Fcgrt 3.556563e-29 0.6325739 0.354 0.024 5.454700e-25
## Eomes 8.948324e-32 0.5895790 0.632 0.229 1.372404e-27
## 1700025G04Rik 2.110652e-28 0.5396917 0.576 0.226 3.237108e-24
## Gpr183 4.596036e-23 0.5187849 0.648 0.312 7.048940e-19
## Il6ra 4.237331e-29 0.5164693 0.333 0.010 6.498795e-25
## Fam169b 1.902254e-22 0.5099275 0.487 0.188 2.917487e-18
## Cst7 2.836682e-25 0.5020259 0.734 0.382 4.350619e-21
## Tspan32 1.302275e-34 -0.5003071 0.132 0.403 1.997300e-30
## Trgv2 1.621841e-49 -0.5725560 0.070 0.340 2.487417e-45
## Tcrg-C2 1.152527e-48 -0.6146709 0.088 0.378 1.767630e-44
## Tsc22d1 3.463883e-109 -0.6396199 0.015 0.299 5.312557e-105
## Lrmp 3.197229e-43 -0.6961183 0.236 0.573 4.903590e-39
## Trat1 4.062804e-139 -0.7221237 0.016 0.365 6.231123e-135
## Xcl1 2.486283e-06 -0.7228213 0.679 0.399 3.813212e-02
## Ptms 5.839556e-120 -0.8734013 0.044 0.444 8.956128e-116
## Id3 1.867392e-36 -0.9074082 0.409 0.708 2.864019e-32
## Klhdc2 7.839484e-67 -0.9674867 0.257 0.674 1.202342e-62
## Anxa2 8.089948e-54 -0.9887883 0.433 0.760 1.240755e-49
## Cd160 4.076057e-62 -1.1860458 0.369 0.757 6.251449e-58
## Ifi27l2a 1.185979e-33 -1.2533170 0.421 0.688 1.818936e-29
## Cd7 3.399631e-76 -1.5369624 0.599 0.865 5.214015e-72
## [1] "DE 0 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Nmi 1.059477e-13 -0.5017165 0.438 0.698 1.624920e-09
## Ddx60 9.266061e-28 -0.5106985 0.090 0.358 1.421136e-23
## Ifit3b 7.273721e-66 -0.5125197 0.022 0.289 1.115571e-61
## Irgm1 1.237800e-25 -0.5516633 0.190 0.522 1.898414e-21
## Parp9 1.361770e-32 -0.5623119 0.117 0.440 2.088547e-28
## Pml 3.888055e-33 -0.5835618 0.137 0.478 5.963110e-29
## Cmpk2 6.441108e-70 -0.5844531 0.027 0.327 9.878727e-66
## Dtx3l 6.589228e-20 -0.5877792 0.273 0.572 1.010590e-15
## Eif2ak2 6.406398e-40 -0.5911615 0.095 0.434 9.825492e-36
## Oasl2 4.580541e-58 -0.6510476 0.048 0.371 7.025176e-54
## Herc6 8.139372e-22 -0.6651741 0.191 0.472 1.248336e-17
## Gbp6 2.662881e-67 -0.6784727 0.049 0.409 4.084060e-63
## Gbp4 9.386295e-17 -0.6960153 0.306 0.572 1.439576e-12
## Ifi35 2.896358e-31 -0.7206405 0.321 0.698 4.442145e-27
## Ddx58 1.251287e-25 -0.7379593 0.263 0.585 1.919099e-21
## Samd9l 1.103963e-20 -0.7600536 0.479 0.755 1.693148e-16
## Lgals3bp 4.854196e-34 -0.7989250 0.344 0.748 7.444880e-30
## Jaml 5.520417e-23 -0.8032695 0.378 0.686 8.466663e-19
## Ifi213 2.212081e-33 -0.8381695 0.259 0.642 3.392669e-29
## Ifi214 4.978877e-25 -0.8470156 0.280 0.591 7.636104e-21
## Rsad2 3.033528e-155 -0.8850550 0.010 0.403 4.652521e-151
## Oas3 7.315285e-64 -0.8922970 0.149 0.648 1.121945e-59
## Slfn1 9.561628e-27 -0.9017779 0.476 0.774 1.466467e-22
## Slfn8 3.045024e-34 -0.9110639 0.280 0.654 4.670153e-30
## Parp14 8.831507e-43 -0.9277745 0.288 0.736 1.354488e-38
## Gbp7 8.314393e-26 -0.9400426 0.388 0.698 1.275178e-21
## Isg20 8.348637e-103 -0.9496986 0.032 0.434 1.280430e-98
## Xaf1 1.504582e-64 -0.9543744 0.204 0.736 2.307577e-60
## Phf11b 2.417098e-32 -0.9760424 0.262 0.616 3.707104e-28
## Rtp4 1.044716e-76 -0.9839878 0.142 0.686 1.602282e-72
## [1] "DE 0 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Il7r 5.687253e-33 1.3468465 0.914 0.496 8.722540e-29
## Bcl2 1.282996e-27 0.9575241 0.911 0.585 1.967731e-23
## Hopx 3.649809e-21 0.7588047 0.804 0.415 5.597712e-17
## Ssh2 2.847469e-16 0.6633845 0.751 0.423 4.367163e-12
## Cmah 3.462438e-15 0.6578409 0.731 0.382 5.310341e-11
## Ifngr1 2.496458e-17 0.6525518 0.772 0.431 3.828818e-13
## Rabac1 4.096061e-18 0.6513783 0.869 0.610 6.282129e-14
## Txnip 1.646674e-13 0.6419796 0.825 0.553 2.525503e-09
## Gm26740 5.263498e-15 0.6270198 0.639 0.285 8.072626e-11
## Smad7 2.240722e-14 0.6163439 0.797 0.528 3.436596e-10
## Clec2d 2.016166e-14 0.6020487 0.848 0.593 3.092194e-10
## S1pr1 2.063528e-13 0.5691949 0.812 0.528 3.164833e-09
## Gramd3 6.224992e-13 0.5673435 0.804 0.537 9.547271e-09
## Samhd1 5.661167e-13 0.5455845 0.646 0.333 8.682531e-09
## 5031425E22Rik 4.108339e-12 0.5435444 0.638 0.333 6.300960e-08
## Tecpr1 6.648351e-12 0.5355404 0.515 0.203 1.019658e-07
## Gm8369 1.008995e-09 0.5318741 0.511 0.228 1.547496e-05
## Klk8 9.465942e-12 0.5273431 0.796 0.537 1.451792e-07
## Use1 6.618404e-12 0.5238268 0.732 0.472 1.015065e-07
## Tcp11l2 1.276707e-12 0.5187986 0.428 0.106 1.958086e-08
## Tmem59 3.664101e-12 0.5034116 0.609 0.309 5.619632e-08
## Stip1 3.254109e-13 -0.5050515 0.358 0.642 4.990827e-09
## Trip13 2.463750e-118 -0.5052237 0.012 0.374 3.778653e-114
## Cdc7 5.117121e-57 -0.5053760 0.045 0.398 7.848128e-53
## Plk4 1.786909e-58 -0.5064806 0.038 0.374 2.740583e-54
## Cdc25a 6.466220e-58 -0.5109883 0.051 0.423 9.917242e-54
## Cdk2 2.656038e-70 -0.5110193 0.026 0.350 4.073566e-66
## Pold1 2.685514e-40 -0.5120564 0.075 0.423 4.118774e-36
## Nsmce4a 6.144450e-16 -0.5125985 0.409 0.699 9.423744e-12
## Rbl1 5.395609e-36 -0.5141296 0.094 0.455 8.275246e-32
## [1] "DE 1 vs 1"
## [1] "DE 1 vs 2"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 6.357531e-280 1.6450342 0.965 0.662 9.750546e-276
## Dusp2 2.287990e-176 1.1771690 0.880 0.519 3.509091e-172
## Fosb 5.390580e-194 1.1592376 0.949 0.682 8.267533e-190
## Tnfaip3 1.359104e-148 0.9744124 0.704 0.276 2.084458e-144
## Klf6 2.046000e-139 0.9340435 0.900 0.631 3.137950e-135
## Dusp1 2.556267e-110 0.8822190 0.848 0.592 3.920546e-106
## Zfp36 1.665389e-120 0.8495240 0.854 0.558 2.554207e-116
## Cd8b1 1.015216e-71 0.7838201 0.768 0.515 1.557037e-67
## Nfkbia 1.720145e-99 0.7470457 0.823 0.515 2.638186e-95
## Coq10b 4.394373e-120 0.7187801 0.700 0.309 6.739650e-116
## Rgs1 5.842360e-73 0.6947237 0.700 0.399 8.960427e-69
## Klf4 5.082412e-71 0.6415308 0.432 0.144 7.794895e-67
## Odc1 1.704636e-56 0.5217513 0.471 0.213 2.614401e-52
## Ppp1r15a 3.909732e-56 0.5079126 0.719 0.463 5.996356e-52
## Ikzf2 1.292491e-52 -0.5487456 0.497 0.770 1.982293e-48
## Klrc2 7.243188e-66 -0.5507730 0.232 0.515 1.110888e-61
## Klre1 1.080643e-99 -0.8260378 0.431 0.764 1.657383e-95
## Klrk1 8.959041e-89 -0.8695972 0.328 0.675 1.374048e-84
## [1] "DE 1 vs 3"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 0.000000e+00 1.9329691 0.963 0.620 0.000000e+00
## Xcl1 1.821458e-271 1.6612848 0.695 0.023 2.793570e-267
## Il2rb 0.000000e+00 1.5217884 0.939 0.429 0.000000e+00
## Klra7 2.812232e-167 1.2557966 0.525 0.040 4.313120e-163
## Ikzf2 1.079863e-140 1.1951366 0.497 0.059 1.656185e-136
## Ccl4 2.347069e-109 1.1806520 0.368 0.021 3.599700e-105
## Klrk1 1.629613e-86 1.1422794 0.328 0.034 2.499338e-82
## Klre1 8.625299e-136 1.0725504 0.431 0.022 1.322862e-131
## Ahnak 2.432630e-145 1.0611132 0.759 0.322 3.730925e-141
## Hopx 3.820727e-196 1.0285452 0.771 0.210 5.859848e-192
## Rgs1 2.992207e-114 0.9118119 0.700 0.282 4.589147e-110
## Klra6 7.460886e-132 0.8609157 0.429 0.025 1.144276e-127
## Ms4a4c 7.532590e-123 0.8599854 0.658 0.222 1.155273e-118
## Cxcr3 1.032386e-185 0.8540616 0.561 0.036 1.583371e-181
## Eomes 4.363501e-138 0.8421492 0.525 0.081 6.692302e-134
## Rhob 1.516963e-109 0.8267152 0.621 0.209 2.326566e-105
## 1700025G04Rik 1.873568e-163 0.8055446 0.511 0.033 2.873491e-159
## Gzmm 2.543794e-87 0.7889548 0.302 0.015 3.901417e-83
## Cd44 1.861568e-160 0.7807277 0.498 0.030 2.855087e-156
## Il18r1 2.518798e-119 0.7651487 0.612 0.182 3.863081e-115
## Anxa2 2.929895e-121 0.7479088 0.463 0.060 4.493580e-117
## Bcl2 5.524738e-101 0.7352592 0.872 0.553 8.473291e-97
## Samd3 2.705096e-157 0.7298622 0.476 0.019 4.148806e-153
## Zyx 7.568937e-105 0.7205574 0.782 0.393 1.160848e-100
## Itgb1 1.250515e-107 0.7150457 0.534 0.131 1.917915e-103
## Pglyrp1 4.943804e-118 0.6943439 0.502 0.090 7.582313e-114
## Ifngr1 6.866232e-100 0.6878548 0.776 0.377 1.053074e-95
## Traf1 7.322744e-69 0.6699173 0.655 0.337 1.123089e-64
## Ctsw 1.834904e-102 0.6634842 0.914 0.634 2.814193e-98
## Id3 3.790600e-70 0.6600148 0.559 0.245 5.813644e-66
## [1] "DE 1 vs 4"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 5.692897e-253 2.4369507 0.965 0.222 8.731196e-249
## Jun 1.789607e-241 2.1546292 0.988 0.474 2.744721e-237
## Fosb 1.794253e-218 1.8793124 0.949 0.340 2.751846e-214
## Cd69 1.127458e-186 1.6302781 0.973 0.649 1.729183e-182
## Dusp1 1.839279e-172 1.6224677 0.848 0.219 2.820902e-168
## Bcl2 1.776793e-195 1.5917000 0.872 0.192 2.725068e-191
## Sell 4.563782e-202 1.5335860 0.929 0.246 6.999472e-198
## Junb 8.870883e-197 1.5184168 0.986 0.677 1.360527e-192
## Xcl1 4.492392e-133 1.4478051 0.695 0.093 6.889981e-129
## Smad7 1.050656e-168 1.3213698 0.920 0.419 1.611391e-164
## Txk 1.836715e-153 1.3064921 0.904 0.405 2.816970e-149
## Zfp36 4.702269e-148 1.2901545 0.854 0.302 7.211870e-144
## Dusp2 2.290233e-118 1.2479608 0.880 0.517 3.512530e-114
## Btg1 7.186291e-155 1.2397253 0.999 0.734 1.102161e-150
## Klf6 3.239987e-128 1.1982162 0.900 0.502 4.969168e-124
## Btg2 2.682986e-126 1.1976693 0.939 0.622 4.114896e-122
## Satb1 1.361361e-151 1.1851584 0.837 0.243 2.087920e-147
## Rhob 4.040870e-119 1.1694320 0.621 0.063 6.197482e-115
## Rgs10 9.505840e-140 1.1269617 0.836 0.269 1.457911e-135
## Il7r 1.364041e-99 1.1208603 0.847 0.397 2.092030e-95
## Ier2 1.141556e-128 1.0963507 0.932 0.603 1.750804e-124
## Tsc22d3 1.455743e-114 1.0857394 0.784 0.282 2.232673e-110
## Ikzf2 7.506249e-73 1.0771298 0.497 0.083 1.151233e-68
## Snhg8 2.148578e-133 1.0432489 0.929 0.600 3.295274e-129
## Tnfaip3 1.918861e-102 1.0346626 0.704 0.216 2.942957e-98
## Nfkbia 2.831745e-98 0.9930551 0.823 0.403 4.343047e-94
## Egr1 9.376803e-64 0.9874131 0.557 0.180 1.438120e-59
## Ier5 4.884206e-109 0.9688323 0.847 0.427 7.490907e-105
## Ms4a4c 1.852343e-94 0.9603520 0.658 0.175 2.840938e-90
## Eif4a2 7.624669e-107 0.9324752 0.863 0.498 1.169396e-102
## [1] "DE 1 vs 5"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Jun 4.589273e-179 3.032534 0.988 0.168 7.038569e-175
## Fos 2.675612e-172 2.877368 0.965 0.074 4.103586e-168
## Btg1 4.789952e-179 2.819630 0.999 0.300 7.346350e-175
## Fosb 1.701164e-153 2.205192 0.949 0.165 2.609076e-149
## Junb 1.232461e-159 2.201332 0.986 0.353 1.890225e-155
## Il7r 4.136396e-131 2.073457 0.847 0.056 6.343990e-127
## Sell 3.060655e-162 2.066969 0.929 0.029 4.694126e-158
## Cd69 1.204393e-137 2.015805 0.973 0.450 1.847177e-133
## Btg2 3.892329e-137 1.943601 0.939 0.306 5.969665e-133
## Bcl2 2.147561e-146 1.939937 0.872 0.021 3.293715e-142
## Txk 5.970666e-146 1.939518 0.904 0.106 9.157210e-142
## Pdcd4 1.199869e-156 1.927528 0.952 0.185 1.840239e-152
## Dusp1 9.581782e-127 1.916219 0.848 0.109 1.469558e-122
## Smad7 2.968122e-144 1.792511 0.920 0.179 4.552209e-140
## Ltb 1.929698e-129 1.677586 0.987 0.432 2.959577e-125
## Tcf7 3.061160e-135 1.671790 0.893 0.097 4.694901e-131
## Gas5 1.078605e-149 1.671461 0.994 0.671 1.654256e-145
## Zfp36 9.968784e-124 1.660443 0.854 0.150 1.528912e-119
## Xcl1 1.564767e-95 1.654517 0.695 0.018 2.399884e-91
## Ier2 1.851057e-127 1.612250 0.932 0.382 2.838966e-123
## Satb1 9.815902e-133 1.602619 0.837 0.047 1.505465e-128
## Rgs10 5.842355e-130 1.602411 0.836 0.053 8.960419e-126
## Rps27rt 2.135440e-141 1.590921 0.947 0.344 3.275125e-137
## Klf6 1.203207e-110 1.564645 0.900 0.350 1.845359e-106
## Dusp2 1.362476e-96 1.534869 0.880 0.397 2.089630e-92
## Tsc22d3 2.770105e-111 1.516575 0.784 0.085 4.248510e-107
## Ccnd2 1.054438e-107 1.482199 0.869 0.291 1.617191e-103
## Zfp36l2 4.754585e-109 1.474316 0.929 0.462 7.292107e-105
## Snhg8 7.761413e-123 1.465603 0.929 0.391 1.190368e-118
## Srsf5 7.030509e-133 1.446723 0.980 0.574 1.078269e-128
## [1] "DE 1 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ccl4 1.789089e-21 1.0198040 0.368 0.083 2.743926e-17
## Egr1 9.669782e-23 0.8484836 0.557 0.267 1.483054e-18
## Dusp2 2.367398e-34 0.8303611 0.880 0.615 3.630879e-30
## Gzmm 1.174552e-22 0.7728497 0.302 0.028 1.801410e-18
## Thy1 3.999620e-43 0.7587722 0.901 0.611 6.134218e-39
## Dusp1 2.922131e-26 0.6637640 0.848 0.552 4.481673e-22
## Coq10b 1.685819e-36 0.6605421 0.700 0.292 2.585540e-32
## Ms4a4c 5.870000e-30 0.6278959 0.658 0.278 9.002819e-26
## Gpr183 3.391463e-26 0.5949936 0.670 0.312 5.201487e-22
## Ccr7 9.192553e-25 0.5823970 0.458 0.132 1.409862e-20
## Ppp1r15a 2.185798e-23 0.5557633 0.719 0.406 3.352359e-19
## Klk8 8.984600e-22 0.5322262 0.716 0.424 1.377968e-17
## Traf1 6.053451e-16 0.5170212 0.655 0.389 9.284178e-12
## Tsc22d1 3.562531e-67 -0.6065965 0.028 0.299 5.463854e-63
## Trat1 6.276375e-58 -0.6442488 0.061 0.365 9.626077e-54
## Lrmp 1.767117e-37 -0.6603900 0.240 0.573 2.710227e-33
## Klhdc2 7.218028e-44 -0.8329760 0.327 0.674 1.107029e-39
## Ptms 2.136624e-96 -0.8574628 0.049 0.444 3.276941e-92
## Anxa2 8.440982e-42 -0.8755906 0.463 0.760 1.294593e-37
## Klra6 4.729124e-37 -0.9716384 0.429 0.726 7.253058e-33
## Cd160 1.372247e-43 -1.0016973 0.419 0.757 2.104616e-39
## Fcer1g 2.529577e-71 -1.4281601 0.185 0.632 3.879612e-67
## Cd7 9.697058e-75 -1.5398524 0.535 0.865 1.487238e-70
## Itga4 1.535939e-104 -1.6328703 0.388 0.903 2.355670e-100
## Ikzf2 7.525555e-118 -1.8425683 0.497 0.976 1.154194e-113
## [1] "DE 1 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fosb 1.520074e-31 0.9702799 0.949 0.660 2.331338e-27
## Fos 1.935537e-29 0.9680633 0.965 0.660 2.968533e-25
## Dusp1 6.193592e-24 0.9280607 0.848 0.572 9.499112e-20
## Nfkbia 4.795354e-18 0.6960847 0.823 0.516 7.354634e-14
## Tnfaip3 1.002462e-16 0.6801404 0.704 0.358 1.537476e-12
## Rgs1 1.109871e-14 0.6731014 0.700 0.409 1.702209e-10
## Zfp36 2.792917e-16 0.6234359 0.854 0.579 4.283498e-12
## Nmi 3.164856e-14 -0.5143386 0.426 0.698 4.853940e-10
## Ifit2 6.425442e-30 -0.5145843 0.074 0.346 9.854701e-26
## Trim30d 5.892051e-28 -0.5270726 0.103 0.396 9.036639e-24
## Ifit3b 8.719973e-80 -0.5300078 0.011 0.289 1.337382e-75
## Parp9 2.930858e-27 -0.5421895 0.129 0.440 4.495057e-23
## Daxx 4.717344e-17 -0.5447300 0.188 0.447 7.234991e-13
## Ddx60 1.078801e-37 -0.5489546 0.064 0.358 1.654558e-33
## Trim12c 6.367643e-21 -0.5763375 0.292 0.616 9.766055e-17
## Mitd1 1.352833e-18 -0.5778749 0.316 0.623 2.074839e-14
## Gbp9 7.716447e-21 -0.5827334 0.126 0.384 1.183472e-16
## Cmpk2 9.977466e-64 -0.5887013 0.025 0.327 1.530244e-59
## Eif2ak2 7.538058e-41 -0.5974394 0.086 0.434 1.156112e-36
## Irgm1 2.001985e-34 -0.6151602 0.149 0.522 3.070445e-30
## Pml 5.104004e-40 -0.6253672 0.112 0.478 7.828011e-36
## Gm20559 5.802890e-16 -0.6276165 0.362 0.623 8.899892e-12
## Dtx3l 4.521676e-23 -0.6285707 0.247 0.572 6.934894e-19
## Oasl2 5.463565e-53 -0.6451031 0.046 0.371 8.379470e-49
## Ifit1bl1 8.165143e-23 -0.6715210 0.158 0.447 1.252288e-18
## Herc6 4.383201e-23 -0.6779556 0.177 0.472 6.722515e-19
## Gbp6 1.913559e-63 -0.6869360 0.046 0.409 2.934826e-59
## Psmb9 6.968697e-24 -0.7182113 0.616 0.912 1.068789e-19
## Ifi35 1.287852e-30 -0.7226112 0.316 0.698 1.975179e-26
## Gbp4 1.276764e-18 -0.7346819 0.288 0.572 1.958173e-14
## [1] "DE 1 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 1.184146e-45 1.7106394 0.965 0.463 1.816125e-41
## Junb 6.299352e-47 1.4997432 0.986 0.602 9.661316e-43
## Dusp2 1.176236e-36 1.4290909 0.880 0.390 1.803993e-32
## Cd69 8.266742e-39 1.4029999 0.973 0.626 1.267870e-34
## Jun 6.835795e-40 1.3734274 0.988 0.732 1.048406e-35
## Btg2 6.883190e-34 1.2531128 0.939 0.561 1.055675e-29
## Dusp1 5.247304e-29 1.2189838 0.848 0.455 8.047790e-25
## Smad7 8.019536e-39 1.2122928 0.920 0.528 1.229956e-34
## Ier2 6.547375e-37 1.1991797 0.932 0.561 1.004171e-32
## Fosb 7.449394e-33 1.1833751 0.949 0.553 1.142514e-28
## Klf6 1.809298e-30 1.1314520 0.900 0.496 2.774921e-26
## Zfp36 1.014662e-28 1.1018238 0.854 0.439 1.556187e-24
## Rgs1 9.662655e-25 1.0598061 0.700 0.211 1.481961e-20
## Il7r 1.792568e-19 1.0023042 0.847 0.496 2.749261e-15
## Tsc22d3 2.338098e-25 0.9847189 0.784 0.309 3.585942e-21
## Nfkbia 2.657104e-22 0.9379597 0.823 0.415 4.075200e-18
## Bcl2 1.341113e-22 0.9006248 0.872 0.585 2.056865e-18
## Tnfaip3 4.757678e-19 0.8786148 0.704 0.301 7.296850e-15
## Ier5 3.294126e-23 0.8648415 0.847 0.488 5.052201e-19
## Pnrc1 1.046423e-23 0.8616076 0.878 0.585 1.604899e-19
## Ifngr1 1.800454e-19 0.7908604 0.776 0.431 2.761356e-15
## Traf1 3.210026e-15 0.7897648 0.655 0.301 4.923216e-11
## 5031425E22Rik 9.430665e-19 0.7747498 0.710 0.333 1.446381e-14
## Rhob 1.645220e-13 0.7609194 0.621 0.285 2.523273e-09
## Ppp1r15a 4.127069e-17 0.7414603 0.719 0.358 6.329686e-13
## Coq10b 2.612546e-19 0.7381859 0.700 0.301 4.006862e-15
## Ssh2 7.806712e-18 0.7234202 0.767 0.423 1.197315e-13
## Hopx 8.406496e-18 0.7075096 0.771 0.415 1.289304e-13
## Clk1 1.966644e-14 0.6547000 0.747 0.398 3.016242e-10
## 2810013P06Rik 3.859410e-14 0.6466957 0.598 0.260 5.919177e-10
## [1] "DE 2 vs 2"
## [1] "DE 2 vs 3"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 0.000000e+00 2.4504683 0.988 0.620 0.000000e+00
## Klra7 1.672003e-278 2.1509365 0.751 0.040 2.564351e-274
## Klrk1 6.938216e-241 2.0118766 0.675 0.034 1.064114e-236
## Klre1 3.497099e-296 1.8985881 0.764 0.022 5.363500e-292
## Ikzf2 7.542741e-272 1.7438822 0.770 0.059 1.156830e-267
## Xcl1 4.276412e-299 1.7243479 0.775 0.023 6.558734e-295
## S100a6 3.728753e-148 1.6622130 0.827 0.541 5.718788e-144
## Il2rb 0.000000e+00 1.6532313 0.968 0.429 0.000000e+00
## Ahnak 3.725870e-203 1.3805595 0.854 0.322 5.714367e-199
## Klra6 3.555510e-201 1.3803560 0.596 0.025 5.453085e-197
## Hopx 1.057247e-196 1.1742261 0.794 0.210 1.621499e-192
## Anxa2 5.060001e-206 1.1662129 0.658 0.060 7.760523e-202
## Ms4a4c 3.429945e-155 1.1413446 0.733 0.222 5.260506e-151
## Il18r1 1.613057e-173 1.1141745 0.728 0.182 2.473945e-169
## Klra1 4.404638e-84 1.0611632 0.295 0.012 6.755394e-80
## Itgb1 1.216822e-160 1.0422491 0.663 0.131 1.866240e-156
## Pglyrp1 5.250328e-165 1.0094974 0.619 0.090 8.052427e-161
## Eomes 8.736195e-171 1.0006867 0.617 0.081 1.339870e-166
## Klrc2 1.121632e-176 0.9786958 0.515 0.007 1.720247e-172
## Fcer1g 4.863631e-131 0.9750446 0.413 0.009 7.459352e-127
## Cxcr3 9.045137e-203 0.9671653 0.620 0.036 1.387253e-198
## Samd3 2.071655e-184 0.9495244 0.554 0.019 3.177297e-180
## Bcl2 1.065648e-116 0.9095947 0.899 0.553 1.634384e-112
## Cd160 9.924807e-140 0.9003040 0.571 0.094 1.522168e-135
## 1700025G04Rik 9.137632e-169 0.8831576 0.544 0.033 1.401439e-164
## Cd7 3.271894e-120 0.8596682 0.709 0.242 5.018104e-116
## Plek 2.949042e-152 0.8513268 0.490 0.024 4.522946e-148
## Zyx 9.832644e-113 0.8276073 0.808 0.393 1.508033e-108
## Ctsw 7.941587e-124 0.8213418 0.927 0.634 1.218001e-119
## Ctla2b 2.455750e-139 0.7699456 0.470 0.030 3.766384e-135
## [1] "DE 2 vs 4"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Bcl2 9.424018e-196 1.7660355 0.899 0.192 1.445362e-191
## Sell 9.938758e-210 1.7435735 0.958 0.246 1.524307e-205
## Klra7 1.165827e-136 1.6420461 0.751 0.096 1.788029e-132
## Ikzf2 9.138534e-156 1.6258754 0.770 0.083 1.401577e-151
## Xcl1 2.145032e-154 1.5108682 0.775 0.093 3.289835e-150
## Jun 2.661793e-135 1.3510193 0.940 0.474 4.082392e-131
## Il7r 8.170782e-98 1.2569856 0.843 0.397 1.253153e-93
## Ms4a4c 6.408021e-117 1.2417112 0.733 0.175 9.827982e-113
## Satb1 1.799684e-145 1.2229691 0.849 0.243 2.760176e-141
## Txk 4.759277e-131 1.2186074 0.889 0.405 7.299304e-127
## Rgs10 2.403213e-124 1.1882399 0.821 0.269 3.685808e-120
## Btg1 3.873771e-134 1.1312049 1.000 0.734 5.941202e-130
## Klra6 8.786199e-92 1.1167067 0.596 0.085 1.347539e-87
## Klre1 2.271567e-108 1.1146890 0.764 0.164 3.483903e-104
## Rhob 2.984019e-102 1.0109122 0.591 0.063 4.576591e-98
## Tcf7 4.421326e-97 0.9562968 0.910 0.466 6.780988e-93
## Nsg2 4.044403e-97 0.8849884 0.641 0.123 6.202901e-93
## Pdcd4 7.853220e-94 0.8766685 0.964 0.690 1.204448e-89
## Fos 1.009169e-70 0.7919166 0.662 0.222 1.547763e-66
## Foxp1 2.728432e-70 0.7895502 0.804 0.446 4.184595e-66
## Fcer1g 5.587014e-61 0.7767058 0.413 0.039 8.568803e-57
## Pde2a 5.013443e-80 0.7747066 0.608 0.139 7.689118e-76
## Snhg8 4.686967e-64 0.7508729 0.852 0.600 7.188402e-60
## Txnip 9.817561e-58 0.7440720 0.800 0.465 1.505719e-53
## Samd3 4.384749e-68 0.7412279 0.554 0.135 6.724889e-64
## Dusp1 1.147669e-53 0.7402487 0.592 0.219 1.760180e-49
## Smad7 2.699815e-57 0.7393921 0.752 0.419 4.140706e-53
## Fosb 3.927711e-51 0.7200748 0.682 0.340 6.023930e-47
## Ssh2 1.001442e-59 0.7180615 0.719 0.353 1.535912e-55
## Zbtb20 1.792884e-54 0.7149641 0.444 0.091 2.749746e-50
## [1] "DE 2 vs 5"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Btg1 1.793047e-169 2.711110 1.000 0.300 2.749996e-165
## Sell 1.945642e-163 2.276956 0.958 0.029 2.984031e-159
## Jun 2.899894e-143 2.228924 0.940 0.168 4.447567e-139
## Klra7 3.174132e-107 2.218441 0.751 0.009 4.868166e-103
## Il7r 3.497228e-124 2.209582 0.843 0.056 5.363698e-120
## Bcl2 1.302907e-146 2.114272 0.899 0.021 1.998268e-142
## Ccl5 4.213918e-141 2.109219 1.000 0.685 6.462886e-137
## Pdcd4 2.904554e-155 2.093514 0.964 0.185 4.454714e-151
## Ikzf2 6.120582e-111 1.876449 0.770 0.021 9.387137e-107
## Txk 3.438097e-133 1.851633 0.889 0.106 5.273010e-129
## Tcf7 4.385582e-135 1.815770 0.910 0.097 6.726167e-131
## Ltb 8.011074e-131 1.813919 0.990 0.432 1.228658e-126
## Gas5 2.492603e-147 1.805346 0.995 0.671 3.822906e-143
## Klre1 7.794337e-100 1.733184 0.764 0.050 1.195417e-95
## Xcl1 1.323477e-110 1.717580 0.775 0.018 2.029817e-106
## Rgs10 5.187494e-119 1.663689 0.821 0.053 7.956059e-115
## Satb1 1.715435e-129 1.640430 0.849 0.047 2.630962e-125
## Ms4a4c 7.282573e-96 1.525392 0.733 0.056 1.116928e-91
## Rps27rt 1.107144e-124 1.516554 0.931 0.344 1.698026e-120
## Junb 7.374692e-93 1.452611 0.902 0.353 1.131057e-88
## Zfp36l2 5.873925e-104 1.441952 0.928 0.462 9.008839e-100
## Klra6 8.672052e-73 1.402402 0.596 0.015 1.330033e-68
## Txnip 1.043982e-90 1.377388 0.800 0.197 1.601156e-86
## Lars2 2.062294e-110 1.353819 0.984 0.659 3.162940e-106
## Hcst 1.602529e-109 1.347857 0.997 0.741 2.457799e-105
## 2410006H16Rik 6.853472e-86 1.346820 0.862 0.385 1.051117e-81
## Ccnd2 3.834903e-83 1.327584 0.815 0.291 5.881591e-79
## Foxp1 2.652980e-95 1.322452 0.804 0.182 4.068876e-91
## Grcc10 2.501956e-103 1.316935 0.947 0.497 3.837249e-99
## Rapgef6 1.908631e-93 1.305721 0.787 0.171 2.927267e-89
## [1] "DE 2 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ctla2a 3.270984e-103 1.6620292 0.988 0.729 5.016708e-99
## Klrk1 4.842326e-38 1.1534368 0.675 0.250 7.426675e-34
## Klre1 3.752476e-51 1.1426432 0.764 0.285 5.755173e-47
## Ms4a4c 4.049499e-43 0.9092551 0.733 0.278 6.210717e-39
## Il18r1 3.319137e-39 0.8083242 0.728 0.281 5.090560e-35
## Thy1 6.245277e-40 0.7671743 0.905 0.611 9.578382e-36
## Gzmm 2.194584e-20 0.7362762 0.284 0.028 3.365834e-16
## Plek 1.442437e-29 0.6614441 0.490 0.118 2.212265e-25
## Klrc1 8.725309e-23 0.6501552 0.341 0.049 1.338201e-18
## Eomes 4.951138e-28 0.6023237 0.617 0.229 7.593560e-24
## BE692007 1.712857e-21 0.5646814 0.474 0.156 2.627009e-17
## Klrc2 1.023636e-24 0.5519640 0.515 0.163 1.569950e-20
## 1700025G04Rik 3.897006e-23 0.5461147 0.544 0.226 5.976837e-19
## Cst7 1.288431e-23 0.5413587 0.721 0.382 1.976066e-19
## Cxcr3 7.646618e-23 0.5202987 0.620 0.295 1.172762e-18
## Samd3 2.454155e-21 0.5095878 0.554 0.222 3.763937e-17
## Gramd3 3.611650e-22 0.5059066 0.789 0.455 5.539187e-18
## Ctla2b 5.868733e-21 0.5052025 0.470 0.163 9.000876e-17
## Lrmp 9.199037e-27 -0.6030487 0.287 0.573 1.410856e-22
## Tsc22d1 9.067602e-65 -0.6331722 0.019 0.299 1.390698e-60
## Trat1 9.225569e-64 -0.6792924 0.040 0.365 1.414926e-59
## Klhdc2 9.211550e-29 -0.7162306 0.400 0.674 1.412775e-24
## Id3 1.428501e-24 -0.7772689 0.453 0.708 2.190891e-20
## Ptms 6.544969e-66 -0.8296839 0.070 0.444 1.003802e-61
## Ifi27l2a 1.785209e-30 -1.1696896 0.400 0.688 2.737975e-26
## Itga4 4.722680e-71 -1.3577680 0.502 0.903 7.243175e-67
## [1] "DE 2 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Klrk1 9.100112e-20 1.0422113 0.675 0.302 1.395684e-15
## Klre1 3.787691e-23 0.9706147 0.764 0.390 5.809181e-19
## Klra7 1.869521e-14 0.7734110 0.751 0.447 2.867284e-10
## Klrc2 2.487836e-18 0.7323966 0.515 0.151 3.815593e-14
## Anxa2 2.253086e-14 0.6113718 0.658 0.358 3.455557e-10
## Ikzf2 3.037817e-13 0.5748764 0.770 0.434 4.659100e-09
## Ifit2 3.650076e-24 -0.5016870 0.083 0.346 5.598121e-20
## Ifit3b 1.933994e-61 -0.5284706 0.012 0.289 2.966167e-57
## Ddx60 8.405872e-29 -0.5321166 0.076 0.358 1.289209e-24
## Parp9 9.641064e-27 -0.5486399 0.124 0.440 1.478650e-22
## Daxx 1.255057e-16 -0.5495805 0.185 0.447 1.924881e-12
## Nmi 6.133291e-16 -0.5543308 0.411 0.698 9.406628e-12
## Mitd1 1.623147e-16 -0.5679555 0.338 0.623 2.489420e-12
## Psmb9 2.228533e-15 -0.5711052 0.657 0.912 3.417901e-11
## Irgm1 1.037745e-26 -0.5800571 0.172 0.522 1.591589e-22
## Eif2ak2 7.872165e-34 -0.5911770 0.095 0.434 1.207354e-29
## Cmpk2 1.241900e-57 -0.5933008 0.022 0.327 1.904702e-53
## Pml 8.569819e-33 -0.6054452 0.124 0.478 1.314353e-28
## Dtx3l 9.863937e-22 -0.6243368 0.247 0.572 1.512832e-17
## Gbp6 1.264386e-43 -0.6584492 0.064 0.409 1.939188e-39
## Oasl2 1.282364e-60 -0.6733782 0.029 0.371 1.966761e-56
## Herc6 1.853980e-21 -0.6750659 0.179 0.472 2.843449e-17
## Gbp4 2.098200e-17 -0.7267897 0.289 0.572 3.218009e-13
## Ddx58 1.242593e-23 -0.7350466 0.260 0.585 1.905765e-19
## Ppa1 2.180628e-24 -0.7495456 0.167 0.491 3.344429e-20
## Ifi35 1.022033e-37 -0.7989439 0.262 0.698 1.567492e-33
## Lgals3bp 5.073177e-37 -0.8461111 0.303 0.748 7.780731e-33
## Jaml 2.123304e-27 -0.8645392 0.317 0.686 3.256511e-23
## Ifi213 1.307946e-34 -0.8706327 0.233 0.642 2.005997e-30
## Ifi47 1.397086e-28 -0.8820121 0.571 0.843 2.142710e-24
## [1] "DE 2 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Il7r 3.202601e-21 1.1384294 0.843 0.496 4.911830e-17
## Bcl2 1.223946e-27 1.0749603 0.899 0.585 1.877166e-23
## Klrk1 1.119144e-15 1.0217853 0.675 0.293 1.716432e-11
## Gimap3 1.277240e-29 0.9784582 0.941 0.691 1.958903e-25
## Hopx 2.622752e-21 0.8531905 0.794 0.415 4.022515e-17
## Klra7 7.498051e-12 0.8379796 0.751 0.431 1.149976e-07
## Ifngr1 1.106944e-18 0.8161083 0.762 0.431 1.697720e-14
## Junb 5.090358e-15 0.7510215 0.902 0.602 7.807083e-11
## Ssh2 6.062153e-14 0.6704407 0.719 0.423 9.297524e-10
## Gm26740 3.169870e-14 0.6624198 0.628 0.285 4.861630e-10
## S1pr1 8.677468e-13 0.6421351 0.789 0.528 1.330863e-08
## Samhd1 9.311916e-15 0.6352764 0.669 0.333 1.428169e-10
## Traf1 2.540735e-11 0.6276282 0.608 0.301 3.896725e-07
## Gramd3 6.640959e-13 0.6155311 0.789 0.537 1.018524e-08
## 5031425E22Rik 8.768762e-12 0.6048926 0.628 0.333 1.344865e-07
## Cmah 2.985957e-11 0.6044348 0.670 0.382 4.579563e-07
## Rhob 1.802801e-10 0.6023996 0.591 0.285 2.764956e-06
## Ripor2 3.350282e-11 0.5671213 0.712 0.447 5.138328e-07
## Ypel3 1.434878e-11 0.5645706 0.571 0.285 2.200673e-07
## Nabp1 2.610275e-09 0.5445731 0.573 0.309 4.003378e-05
## Tmem59 1.115003e-10 0.5427361 0.582 0.309 1.710081e-06
## Tsc22d3 1.983024e-10 0.5408897 0.617 0.309 3.041364e-06
## Klre1 5.248431e-10 0.5367211 0.764 0.439 8.049519e-06
## Tecpr1 6.157206e-11 0.5342380 0.505 0.203 9.443307e-07
## Cd69 2.281236e-10 0.5316127 0.880 0.626 3.498731e-06
## 2810013P06Rik 9.895955e-09 0.5040444 0.515 0.260 1.517743e-04
## Gtf2f1 1.415468e-18 -0.5005101 0.213 0.553 2.170903e-14
## Mrps18c 3.096075e-13 -0.5012730 0.362 0.650 4.748450e-09
## Nsmce4a 2.713745e-15 -0.5024414 0.391 0.699 4.162070e-11
## Hmgxb4 1.496000e-26 -0.5025918 0.103 0.439 2.294415e-22
## [1] "DE 3 vs 3"
## [1] "DE 3 vs 4"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Fos 2.263735e-191 2.0029576 0.912 0.222 3.471891e-187
## Jun 1.358090e-175 1.7704778 0.979 0.474 2.082903e-171
## Lef1 3.113143e-174 1.6286282 0.903 0.345 4.774628e-170
## Junb 1.403893e-152 1.4169971 0.971 0.677 2.153150e-148
## Btg1 2.694709e-162 1.3676718 0.998 0.734 4.132875e-158
## Sell 1.061929e-146 1.3646378 0.862 0.246 1.628680e-142
## Satb1 2.433492e-134 1.3221908 0.806 0.243 3.732247e-130
## Smad7 3.323229e-119 1.2584923 0.838 0.419 5.096836e-115
## Ccr7 4.736155e-116 1.1917838 0.715 0.143 7.263841e-112
## Fosb 2.196033e-96 1.1744295 0.780 0.340 3.368056e-92
## Tsc22d3 1.288567e-96 1.1591887 0.746 0.282 1.976276e-92
## Dusp1 4.412799e-87 1.1558592 0.682 0.219 6.767910e-83
## Snhg8 5.081482e-107 1.0185860 0.894 0.600 7.793469e-103
## Ccr9 4.766557e-88 0.9761316 0.465 0.008 7.310468e-84
## Cd69 2.769658e-78 0.9695733 0.923 0.649 4.247825e-74
## Rgs10 1.551118e-79 0.9508100 0.700 0.269 2.378949e-75
## Klf6 2.168971e-67 0.9470318 0.788 0.502 3.326550e-63
## Foxp1 4.850043e-76 0.9302261 0.785 0.446 7.438511e-72
## Eif4a2 8.268613e-87 0.9255956 0.818 0.498 1.268157e-82
## Il7r 2.291421e-64 0.9155552 0.790 0.397 3.514352e-60
## Rps27rt 1.554749e-107 0.8991743 0.965 0.687 2.384519e-103
## Ppp1r15a 4.981459e-69 0.8882769 0.622 0.214 7.640063e-65
## Peli1 8.345846e-67 0.8851985 0.767 0.444 1.280002e-62
## Tdrp 3.696600e-84 0.8842170 0.476 0.027 5.669476e-80
## Snhg12 1.828896e-68 0.8577081 0.608 0.205 2.804978e-64
## Bcl2 2.042619e-56 0.8564408 0.553 0.192 3.132765e-52
## Tcf7 1.114939e-75 0.8549360 0.872 0.466 1.709983e-71
## Txk 6.291976e-60 0.8275740 0.735 0.405 9.650003e-56
## Igfbp4 1.817081e-60 0.7818778 0.347 0.006 2.786857e-56
## Rgcc 6.940867e-59 0.7711264 0.546 0.161 1.064521e-54
## [1] "DE 3 vs 5"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Btg1 9.947140e-170 2.947577 0.998 0.300 1.525593e-165
## Jun 3.904017e-158 2.648383 0.979 0.168 5.987591e-154
## Fos 6.003293e-143 2.443375 0.912 0.074 9.207251e-139
## Junb 2.129709e-138 2.099913 0.971 0.353 3.266335e-134
## Lef1 2.697220e-137 2.047862 0.903 0.135 4.136727e-133
## Ltb 1.012758e-142 2.028040 0.994 0.432 1.553268e-138
## Sell 8.629817e-132 1.898021 0.862 0.029 1.323555e-127
## Il7r 9.274974e-108 1.868152 0.790 0.056 1.422503e-103
## Gas5 2.440355e-145 1.829963 0.997 0.671 3.742772e-141
## Satb1 7.860112e-117 1.739651 0.806 0.047 1.205505e-112
## Smad7 6.051914e-111 1.729633 0.838 0.179 9.281821e-107
## Tcf7 1.654062e-121 1.714409 0.872 0.097 2.536835e-117
## Rps27rt 1.218054e-141 1.691425 0.965 0.344 1.868130e-137
## Pdcd4 6.141185e-122 1.682727 0.891 0.185 9.418736e-118
## Tsc22d3 5.380265e-96 1.590025 0.746 0.085 8.251713e-92
## Ighm 1.324422e-50 1.540951 0.656 0.218 2.031266e-46
## Fosb 1.401849e-87 1.500309 0.780 0.165 2.150016e-83
## Foxp1 7.339262e-93 1.463128 0.785 0.182 1.125623e-88
## Txk 2.602734e-88 1.460600 0.735 0.106 3.991813e-84
## Srsf5 1.319623e-111 1.452007 0.951 0.574 2.023905e-107
## Dusp1 1.577503e-75 1.449610 0.682 0.109 2.419417e-71
## Snhg8 4.307166e-105 1.440940 0.894 0.391 6.605901e-101
## Btg2 1.946978e-87 1.428303 0.842 0.306 2.986081e-83
## Rgs10 4.595587e-88 1.426259 0.700 0.053 7.048252e-84
## Ccnd2 7.137952e-87 1.425803 0.823 0.291 1.094748e-82
## Npc2 2.417802e-114 1.424197 0.946 0.594 3.708183e-110
## Ccr7 4.910590e-92 1.417094 0.715 0.041 7.531373e-88
## Peli1 8.815108e-85 1.395172 0.767 0.191 1.351973e-80
## Pnrc1 4.867312e-90 1.387103 0.831 0.315 7.464997e-86
## Rapgef6 2.586735e-87 1.370643 0.754 0.171 3.967275e-83
## [1] "DE 3 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Dapl1 5.001301e-57 2.2865749 0.595 0.059 7.670496e-53
## Cd8b1 2.598718e-140 2.2247827 0.997 0.562 3.985654e-136
## Ccr7 3.676594e-66 1.2516290 0.715 0.132 5.638792e-62
## Npc2 9.972677e-82 1.1826261 0.946 0.684 1.529509e-77
## Ccr9 2.502370e-41 0.9333703 0.465 0.024 3.837884e-37
## Rgcc 7.158974e-41 0.8938406 0.546 0.101 1.097972e-36
## Thy1 7.591795e-46 0.8460316 0.899 0.611 1.164354e-41
## Igfbp4 4.659377e-31 0.7909372 0.347 0.000 7.146087e-27
## Inpp4b 1.642645e-32 0.7360800 0.453 0.073 2.519325e-28
## Bcl11b 1.826938e-22 0.6576699 0.705 0.441 2.801975e-18
## Gm12840 2.810644e-19 0.6170665 0.304 0.049 4.310685e-15
## Il6ra 1.035886e-27 0.5873657 0.330 0.010 1.588738e-23
## Tdrp 3.117849e-18 0.5809762 0.476 0.208 4.781844e-14
## Klk8 1.210620e-20 0.5697122 0.679 0.424 1.856727e-16
## Rflnb 2.270007e-17 0.5460410 0.405 0.142 3.481509e-13
## Fam169b 1.381803e-18 0.5398058 0.459 0.188 2.119271e-14
## Grap2 6.442597e-18 0.5368788 0.677 0.420 9.881012e-14
## Fam241a 1.558461e-17 0.5290608 0.482 0.212 2.390211e-13
## Slfn1 3.738494e-16 0.5084605 0.438 0.181 5.733729e-12
## Tcrg-C4 1.948847e-73 -0.5012785 0.002 0.267 2.988947e-69
## Mfsd10 4.444562e-36 -0.5142817 0.077 0.344 6.816625e-32
## Mxd4 2.915304e-22 -0.5156629 0.207 0.469 4.471202e-18
## Sptbn1 1.121381e-18 -0.5167836 0.496 0.750 1.719862e-14
## Capns1 6.545557e-23 -0.5258914 0.276 0.566 1.003892e-18
## Tpm4 2.297592e-20 -0.5269669 0.427 0.698 3.523816e-16
## Neurl3 9.459738e-21 -0.5342523 0.243 0.503 1.450840e-16
## Rinl 8.079704e-23 -0.5440639 0.502 0.767 1.239184e-18
## Acot7 3.543344e-61 -0.5473657 0.024 0.316 5.434427e-57
## Prkch 7.242819e-21 -0.5530111 0.380 0.649 1.110831e-16
## Smap1 4.611239e-23 -0.5566948 0.322 0.604 7.072258e-19
## [1] "DE 3 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Dapl1 3.553568e-17 1.3267455 0.595 0.258 5.450107e-13
## Ccr9 5.052730e-19 0.8004840 0.465 0.082 7.749373e-15
## Rgcc 7.909365e-21 0.7317339 0.546 0.126 1.213059e-16
## Ccr7 6.023728e-16 0.7249766 0.715 0.428 9.238591e-12
## Igfbp4 9.462472e-13 0.6119670 0.347 0.063 1.451259e-08
## Rflnb 4.461111e-11 0.5979345 0.405 0.145 6.842006e-07
## Fos 1.439833e-14 0.5340702 0.912 0.660 2.208271e-10
## Inpp4b 6.384821e-10 0.5037209 0.453 0.201 9.792400e-06
## Gm4070 1.409027e-25 -0.5006491 0.118 0.434 2.161025e-21
## Pde2a 5.370316e-22 -0.5010862 0.188 0.522 8.236454e-18
## Sp110 1.167425e-13 -0.5026575 0.410 0.704 1.790480e-09
## Daxx 2.182144e-15 -0.5114217 0.186 0.447 3.346754e-11
## Chsy1 1.440341e-33 -0.5145236 0.068 0.377 2.209051e-29
## Rnf114 2.675550e-16 -0.5163637 0.297 0.591 4.103491e-12
## Ddx60 1.803110e-30 -0.5275689 0.068 0.358 2.765429e-26
## Irgm1 3.292153e-23 -0.5288744 0.182 0.522 5.049174e-19
## Sla 2.728708e-21 -0.5297531 0.205 0.541 4.185020e-17
## Ifit2 8.871678e-34 -0.5329555 0.056 0.346 1.360649e-29
## Ifit3b 3.381134e-68 -0.5356066 0.006 0.289 5.185646e-64
## Helz2 4.455136e-35 -0.5358283 0.092 0.440 6.832842e-31
## Psmb10 6.434827e-16 -0.5419047 0.655 0.912 9.869094e-12
## Anxa2 1.281193e-33 -0.5548411 0.060 0.358 1.964966e-29
## Lgals9 2.216604e-14 -0.5589969 0.253 0.522 3.399606e-10
## Ifih1 1.994781e-34 -0.5595322 0.037 0.289 3.059396e-30
## Tapbp 1.424745e-14 -0.5611618 0.476 0.780 2.185131e-10
## Parp9 3.492050e-30 -0.5614072 0.107 0.440 5.355756e-26
## Nmi 6.392535e-18 -0.5614356 0.356 0.698 9.804231e-14
## Slamf7 1.622729e-59 -0.5680549 0.016 0.314 2.488779e-55
## Dennd4a 1.938330e-24 -0.5703951 0.101 0.390 2.972816e-20
## Cnot6l 6.946608e-17 -0.5755264 0.402 0.723 1.065401e-12
## [1] "DE 3 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Dapl1 4.255229e-16 1.4668224 0.595 0.220 6.526244e-12
## Junb 1.386975e-39 1.3983235 0.971 0.602 2.127203e-35
## Lef1 1.244497e-36 1.2828057 0.903 0.537 1.908686e-32
## Fos 2.517637e-31 1.2766463 0.912 0.463 3.861300e-27
## Smad7 2.757840e-29 1.1494154 0.838 0.528 4.229700e-25
## Gm8369 8.523958e-22 1.0941846 0.659 0.228 1.307319e-17
## Tsc22d3 4.803600e-23 1.0581682 0.746 0.309 7.367282e-19
## Cd8b1 8.335663e-31 1.0261486 0.997 0.691 1.278441e-26
## Ccr7 1.214012e-18 0.8951765 0.715 0.358 1.861930e-14
## Klf6 1.418169e-17 0.8802677 0.788 0.496 2.175045e-13
## Dusp2 2.676971e-14 0.8248369 0.689 0.390 4.105671e-10
## Ccr9 8.603043e-18 0.8006784 0.465 0.041 1.319449e-13
## Il7r 2.439692e-12 0.7969991 0.790 0.496 3.741756e-08
## Peli1 1.866240e-15 0.7948285 0.767 0.504 2.862253e-11
## Rgcc 6.957391e-17 0.7907583 0.546 0.138 1.067055e-12
## 1810026B05Rik 4.906837e-17 0.7650950 0.723 0.398 7.525616e-13
## Actn1 2.918728e-12 0.7536038 0.613 0.341 4.476454e-08
## Cd69 1.347137e-15 0.7422951 0.923 0.626 2.066104e-11
## Btg2 1.182660e-14 0.7378147 0.842 0.561 1.813846e-10
## Ppp1r15a 1.391340e-11 0.7079938 0.622 0.358 2.133898e-07
## Igfbp4 4.090101e-12 0.6890575 0.347 0.033 6.272988e-08
## Tdrp 4.288087e-11 0.6500970 0.476 0.179 6.576639e-07
## Tmem59 6.656155e-11 0.6388843 0.561 0.309 1.020855e-06
## Inpp4b 8.491068e-10 0.5795198 0.453 0.179 1.302275e-05
## Cdca7l 1.023851e-39 -0.5009989 0.071 0.455 1.570280e-35
## Nudt5 2.399596e-26 -0.5013307 0.154 0.545 3.680261e-22
## Cep55 9.957615e-75 -0.5015722 0.005 0.317 1.527199e-70
## Tbcb 2.012019e-23 -0.5030132 0.172 0.553 3.085834e-19
## Smc5 3.035173e-35 -0.5030489 0.075 0.439 4.655045e-31
## Cdv3 6.778813e-14 -0.5031887 0.355 0.699 1.039667e-09
## [1] "DE 4 vs 4"
## [1] "DE 4 vs 5"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Btg1 8.719827e-50 1.5799048 0.734 0.300 1.337360e-45
## Ltb 1.966764e-57 1.3773577 0.872 0.432 3.016426e-53
## Pdcd4 5.049248e-55 1.2168460 0.690 0.185 7.744031e-51
## 2410006H16Rik 5.159059e-36 1.0336419 0.713 0.385 7.912448e-32
## Il7r 5.123349e-30 0.9525963 0.397 0.056 7.857681e-26
## Klrd1 6.601662e-23 0.9417570 0.756 0.500 1.012497e-18
## Jun 2.830597e-23 0.8779050 0.474 0.168 4.341287e-19
## Tcf7 3.242857e-31 0.8594734 0.466 0.097 4.973569e-27
## Gm8369 3.341120e-32 0.8455728 0.783 0.491 5.124275e-28
## Ablim1 3.623853e-36 0.8418751 0.786 0.468 5.557903e-32
## Gimap6 1.110339e-30 0.8322632 0.805 0.521 1.702926e-26
## Grcc10 6.989344e-32 0.8220037 0.787 0.497 1.071956e-27
## Ifi203 5.022246e-34 0.7985799 0.860 0.600 7.702619e-30
## Ccnd2 1.208476e-25 0.7964408 0.600 0.291 1.853439e-21
## Rps27rt 1.482932e-32 0.7922510 0.687 0.344 2.274373e-28
## Zfp36l2 8.095874e-25 0.7740872 0.720 0.462 1.241664e-20
## Zfas1 9.080290e-30 0.7582115 0.523 0.168 1.392644e-25
## Btg2 1.806233e-25 0.7459314 0.622 0.306 2.770219e-21
## Junb 1.327492e-22 0.6829156 0.677 0.353 2.035974e-18
## Gm2682 2.716335e-22 0.6648254 0.680 0.403 4.166043e-18
## Cd7 7.132627e-18 0.6455947 0.369 0.115 1.093931e-13
## Slfn1 1.020385e-25 0.6405983 0.450 0.126 1.564965e-21
## Txnip 5.620627e-19 0.6333157 0.465 0.197 8.620356e-15
## Txk 4.299548e-23 0.6330256 0.405 0.106 6.594217e-19
## Mxd4 6.796643e-24 0.6242396 0.450 0.144 1.042401e-19
## Rapgef6 1.995039e-22 0.6242021 0.463 0.171 3.059792e-18
## Pnrc1 6.387859e-20 0.6201122 0.573 0.315 9.797060e-16
## Ogt 2.339039e-22 0.6037894 0.524 0.224 3.587384e-18
## Gm26740 1.061270e-23 0.5842050 0.446 0.135 1.627670e-19
## Fam189b 2.784632e-20 0.5804443 0.523 0.250 4.270790e-16
## [1] "DE 4 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 8.298625e-105 4.180055 0.929 0.288 1.272760e-100
## Gzma 3.417322e-48 4.061803 0.583 0.080 5.241147e-44
## S100a6 1.088763e-113 3.960106 0.989 0.722 1.669835e-109
## Lgals1 2.907050e-116 3.564711 0.997 0.736 4.458542e-112
## Lgals3 1.081365e-77 2.714480 0.789 0.122 1.658489e-73
## Cd8b1 1.085198e-115 2.572645 0.986 0.562 1.664369e-111
## Gzmb 3.608064e-63 2.540013 0.669 0.062 5.533688e-59
## Stmn1 8.481339e-33 1.976939 0.584 0.236 1.300783e-28
## Pycard 2.793257e-86 1.882299 0.978 0.705 4.284018e-82
## Pclaf 2.925501e-37 1.872937 0.463 0.038 4.486840e-33
## Birc5 1.362301e-36 1.851958 0.438 0.021 2.089361e-32
## Itgb1 5.082183e-68 1.816955 0.901 0.472 7.794545e-64
## Ube2c 3.128815e-36 1.807913 0.458 0.038 4.798664e-32
## Mki67 1.602402e-37 1.754365 0.469 0.038 2.457604e-33
## Ly6a 1.233789e-62 1.658259 0.635 0.021 1.892263e-58
## Vim 1.839909e-63 1.653886 0.967 0.712 2.821869e-59
## Id2 5.717437e-58 1.608192 0.865 0.434 8.768833e-54
## Dapl1 1.032967e-18 1.595834 0.320 0.059 1.584261e-14
## Ccnb2 2.575733e-33 1.494732 0.408 0.021 3.950401e-29
## Plac8 8.122636e-42 1.453735 0.699 0.257 1.245769e-37
## 1500009L16Rik 3.101035e-51 1.441785 0.540 0.007 4.756057e-47
## Cks2 2.935123e-28 1.343547 0.529 0.170 4.501598e-24
## Hist1h2ap 4.619792e-20 1.315647 0.550 0.264 7.085375e-16
## Lmnb1 1.524944e-32 1.314674 0.556 0.163 2.338806e-28
## Ccr2 1.101292e-51 1.298706 0.543 0.007 1.689051e-47
## Dut 2.639504e-28 1.266868 0.661 0.330 4.048207e-24
## Hist1h1b 8.653352e-31 1.239379 0.472 0.090 1.327165e-26
## Cks1b 3.364502e-27 1.236598 0.428 0.087 5.160136e-23
## Top2a 1.412001e-24 1.214793 0.372 0.052 2.165585e-20
## Hmgn2 2.062711e-31 1.199936 0.644 0.295 3.163580e-27
## [1] "DE 4 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## S100a4 1.281140e-67 4.046220 0.929 0.226 1.964885e-63
## Gzma 1.214605e-22 3.812444 0.583 0.201 1.862840e-18
## Lgals1 4.149141e-75 3.563933 0.997 0.704 6.363538e-71
## Lgals3 2.115241e-52 2.882100 0.789 0.075 3.244145e-48
## Gzmb 3.219228e-39 2.548366 0.669 0.063 4.937331e-35
## Stmn1 3.824421e-27 2.161497 0.584 0.126 5.865515e-23
## Itga4 1.684523e-63 2.133223 0.951 0.340 2.583553e-59
## Pycard 3.240861e-63 2.128544 0.978 0.704 4.970508e-59
## Id2 4.123072e-47 1.960310 0.865 0.327 6.323556e-43
## Pclaf 4.177428e-24 1.910340 0.463 0.019 6.406921e-20
## Anxa2 2.269707e-43 1.894317 0.835 0.358 3.481050e-39
## Ube2c 3.087927e-23 1.830962 0.458 0.025 4.735953e-19
## Mki67 1.026647e-23 1.815895 0.469 0.031 1.574568e-19
## Birc5 1.070759e-19 1.798607 0.438 0.057 1.642224e-15
## Itgb1 7.754031e-43 1.776428 0.901 0.478 1.189236e-38
## Cenpa 5.066493e-23 1.674363 0.477 0.044 7.770480e-19
## Ptms 1.108977e-46 1.579568 0.746 0.057 1.700837e-42
## Cd48 1.710136e-53 1.537642 0.969 0.704 2.622835e-49
## Hist1h2ap 2.543333e-16 1.500025 0.550 0.239 3.900711e-12
## Ccnb2 1.720788e-19 1.484709 0.408 0.031 2.639173e-15
## Lmnb1 1.173373e-25 1.469876 0.556 0.101 1.799602e-21
## 1500009L16Rik 1.996976e-30 1.424802 0.540 0.013 3.062762e-26
## Dut 4.332201e-23 1.399911 0.661 0.277 6.644296e-19
## S100a13 1.071449e-52 1.359467 0.984 0.642 1.643281e-48
## Cks2 2.860728e-17 1.328676 0.529 0.182 4.387499e-13
## Atpif1 1.949137e-35 1.279938 0.802 0.321 2.989392e-31
## Top2a 2.303486e-16 1.248816 0.372 0.038 3.532856e-12
## Cks1b 1.507873e-17 1.244952 0.428 0.075 2.312624e-13
## Hist1h1b 8.883052e-19 1.241161 0.472 0.101 1.362394e-14
## Hmgn2 8.047126e-21 1.235481 0.644 0.302 1.234188e-16
## [1] "DE 4 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Gzma 9.984380e-20 3.5489907 0.583 0.154 1.531304e-15
## S100a4 2.672431e-47 3.3529453 0.929 0.463 4.098707e-43
## S100a6 2.213373e-55 3.2695292 0.989 0.642 3.394651e-51
## Lgals3 5.001702e-40 2.7067474 0.789 0.098 7.671110e-36
## Gzmb 2.048048e-26 2.1131467 0.669 0.130 3.141091e-22
## Id2 8.640908e-34 1.7748597 0.865 0.431 1.325256e-29
## Itga4 1.732361e-43 1.7386885 0.951 0.374 2.656922e-39
## Cd8b1 6.549647e-37 1.3740106 0.986 0.691 1.004519e-32
## Ly6a 9.929707e-23 1.3500174 0.635 0.138 1.522919e-18
## Gm8369 1.697094e-31 1.3268844 0.783 0.228 2.602834e-27
## Itgb1 2.672170e-25 1.2998006 0.901 0.569 4.098307e-21
## Tspo 6.168050e-42 1.2865732 0.959 0.699 9.459939e-38
## 1500009L16Rik 2.906086e-18 1.2547324 0.540 0.114 4.457064e-14
## Ptms 4.244542e-26 1.1762222 0.746 0.195 6.509853e-22
## Hopx 1.003153e-28 1.1160713 0.861 0.415 1.538536e-24
## Ctsd 9.859582e-30 1.0973882 0.934 0.659 1.512164e-25
## Gzmk 2.016908e-20 1.0892985 0.494 0.024 3.093331e-16
## Supt4a 4.439995e-34 1.0703955 0.956 0.634 6.809620e-30
## Prr13 2.077682e-26 1.0194499 0.828 0.488 3.186540e-22
## Ahnak 4.544878e-24 0.9943089 0.918 0.626 6.970479e-20
## Atox1 6.751675e-28 0.9624601 0.913 0.634 1.035504e-23
## Samhd1 1.776179e-21 0.9546094 0.751 0.333 2.724125e-17
## Ccdc12 1.006152e-29 0.9340213 0.924 0.626 1.543136e-25
## S1pr4 8.422583e-23 0.9333075 0.761 0.333 1.291772e-18
## Aldoa 1.268095e-21 0.8972463 0.860 0.455 1.944877e-17
## Gimap1 9.425433e-24 0.8926137 0.921 0.593 1.445579e-19
## Serpinb6b 2.141092e-15 0.8637096 0.658 0.317 3.283792e-11
## Map1lc3b 2.962328e-22 0.8520999 0.880 0.585 4.543323e-18
## Klrk1 9.275900e-14 0.8518674 0.687 0.293 1.422645e-09
## Cx3cr1 2.130780e-11 0.8518385 0.309 0.016 3.267977e-07
## [1] "DE 5 vs 5"
## [1] "DE 5 vs 6"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Hist1h2ap 1.119511e-107 5.627405 1.000 0.264 1.716994e-103
## Hist1h1b 1.523655e-111 5.199805 1.000 0.090 2.336829e-107
## Hist1h2ae 1.328971e-110 5.147012 1.000 0.125 2.038243e-106
## Gzma 1.539604e-69 4.363418 0.776 0.080 2.361291e-65
## S100a4 9.194939e-101 4.344509 0.985 0.288 1.410228e-96
## S100a6 1.034386e-102 4.060233 1.000 0.722 1.586438e-98
## Lgals1 1.000657e-103 4.023067 1.000 0.736 1.534708e-99
## Hist1h4d 2.411175e-105 3.900633 1.000 0.396 3.698020e-101
## Pclaf 3.269128e-113 3.810257 1.000 0.038 5.013861e-109
## Stmn1 2.941898e-108 3.656197 1.000 0.236 4.511988e-104
## Top2a 1.430245e-112 3.634038 1.000 0.052 2.193566e-108
## Mki67 8.830157e-112 3.552852 0.997 0.038 1.354281e-107
## Hist1h3c 1.016192e-113 3.405981 0.997 0.007 1.558534e-109
## Hist1h2ab 8.238999e-114 3.403212 1.000 0.017 1.263615e-109
## Birc5 4.006885e-113 3.304994 0.997 0.021 6.145359e-109
## Lgals3 2.260456e-98 3.218854 0.956 0.122 3.466862e-94
## Hist2h2ac 3.908127e-108 3.160507 1.000 0.184 5.993894e-104
## Gzmb 6.846512e-89 3.126829 0.882 0.062 1.050049e-84
## Ube2c 1.845166e-85 3.053316 0.850 0.038 2.829932e-81
## Tuba1b 4.879780e-105 2.916903 1.000 0.410 7.484118e-101
## Hist1h2bj 1.082086e-110 2.894943 0.985 0.024 1.659596e-106
## Hist1h3e 6.619983e-107 2.881411 0.997 0.181 1.015307e-102
## Hist1h1d 8.525464e-107 2.814737 1.000 0.174 1.307550e-102
## H2afx 1.726467e-102 2.673931 0.988 0.170 2.647882e-98
## Cks2 2.688551e-103 2.638789 0.985 0.170 4.123430e-99
## Hist1h1e 9.079472e-100 2.564008 1.000 0.736 1.392519e-95
## Rrm2 4.799962e-107 2.530633 0.968 0.031 7.361701e-103
## Lmnb1 1.550980e-106 2.504998 0.997 0.163 2.378737e-102
## Nusap1 2.168805e-99 2.481798 0.918 0.010 3.326296e-95
## Tubb4b 9.986142e-92 2.480848 0.988 0.444 1.531575e-87
## [1] "DE 5 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Hist1h2ap 1.473709e-73 5.811783 1.000 0.239 2.260228e-69
## Hist1h2ae 3.398291e-74 5.206554 1.000 0.107 5.211959e-70
## Hist1h1b 3.127311e-74 5.201587 1.000 0.101 4.796357e-70
## S100a4 3.181201e-68 4.210674 0.985 0.226 4.879009e-64
## Hist1h4d 2.646063e-73 4.193616 1.000 0.277 4.058267e-69
## Gzma 3.971651e-39 4.114059 0.776 0.201 6.091321e-35
## Lgals1 1.616857e-72 4.022290 1.000 0.704 2.479774e-68
## Pclaf 7.284146e-75 3.847661 1.000 0.019 1.117169e-70
## Stmn1 3.573375e-74 3.840756 1.000 0.126 5.480485e-70
## S100a6 8.860402e-71 3.697440 1.000 0.742 1.358920e-66
## Top2a 1.199950e-74 3.668062 1.000 0.038 1.840363e-70
## Mki67 2.793954e-74 3.614382 0.997 0.031 4.285087e-70
## Hist1h1e 1.899516e-72 3.541110 1.000 0.453 2.913288e-68
## Hist1h3c 1.669492e-74 3.397931 0.997 0.013 2.560500e-70
## Hist1h2ab 9.285112e-75 3.397114 1.000 0.025 1.424058e-70
## Lgals3 1.142174e-67 3.386474 0.956 0.075 1.751753e-63
## Birc5 5.230045e-74 3.251644 0.997 0.057 8.021320e-70
## Hist2h2ac 3.694411e-73 3.172571 1.000 0.189 5.666119e-69
## Gzmb 3.637317e-58 3.135182 0.882 0.063 5.578553e-54
## Ube2c 5.820848e-56 3.076364 0.850 0.025 8.927434e-52
## Hist1h1d 4.511791e-74 3.051308 1.000 0.088 6.919734e-70
## Hist1h3e 7.993228e-73 2.957620 0.997 0.126 1.225921e-68
## Hist1h2bj 1.341286e-72 2.877181 0.985 0.038 2.057130e-68
## Tuba1b 2.582097e-72 2.755971 1.000 0.503 3.960163e-68
## Lmnb1 1.530806e-73 2.660200 0.997 0.101 2.347797e-69
## Cks2 1.963452e-69 2.623918 0.985 0.182 3.011347e-65
## Tubb4b 2.067968e-65 2.605528 0.988 0.421 3.171643e-61
## H2afx 1.271300e-67 2.570249 0.988 0.252 1.949793e-63
## Rrm2 9.858003e-71 2.556994 0.968 0.013 1.511922e-66
## Dut 2.385487e-66 2.525310 0.976 0.277 3.658621e-62
## [1] "DE 5 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Gzma 5.006562e-33 3.850606 0.776 0.154 7.678564e-29
## S100a4 3.087260e-53 3.517399 0.985 0.463 4.734930e-49
## S100a6 1.988813e-58 3.369656 1.000 0.642 3.050242e-54
## Lgals3 2.607519e-54 3.211121 0.956 0.098 3.999152e-50
## Gzmb 2.596351e-43 2.699963 0.882 0.130 3.982023e-39
## Hist1h1b 3.023931e-49 2.478645 1.000 0.415 4.637803e-45
## Hist1h2ae 4.506001e-51 2.288165 1.000 0.537 6.910853e-47
## 1500009L16Rik 2.602647e-51 2.099205 0.944 0.114 3.991679e-47
## Id2 2.206425e-39 2.007610 0.932 0.431 3.383995e-35
## Hist1h4d 4.036804e-44 1.784254 1.000 0.691 6.191246e-40
## Hist1h2ab 5.919285e-43 1.764449 1.000 0.455 9.078407e-39
## Cd48 1.600685e-51 1.721638 1.000 0.740 2.454971e-47
## Itga4 2.649608e-42 1.714189 0.988 0.374 4.063703e-38
## Hist1h2bj 9.983320e-42 1.605727 0.985 0.480 1.531142e-37
## Ube2c 4.868183e-21 1.595292 0.850 0.431 7.466333e-17
## Hist1h3e 1.534077e-39 1.594946 0.997 0.520 2.352813e-35
## Hist2h2ac 8.651475e-39 1.590364 1.000 0.561 1.326877e-34
## Hist1h2ap 2.928898e-38 1.559959 1.000 0.626 4.492052e-34
## Hist1h3c 9.839415e-35 1.404284 0.997 0.545 1.509071e-30
## Ly6a 8.991694e-27 1.387273 0.726 0.138 1.379056e-22
## Ptms 4.782006e-34 1.334645 0.879 0.195 7.334162e-30
## Gzmk 2.431785e-30 1.319558 0.671 0.024 3.729629e-26
## Hist1h1e 2.740948e-30 1.317846 1.000 0.715 4.203792e-26
## Cmtm7 1.781607e-36 1.277841 0.941 0.577 2.732450e-32
## Pclaf 1.636943e-40 1.277198 1.000 0.691 2.510579e-36
## Birc5 6.226368e-30 1.235031 0.997 0.561 9.549380e-26
## Hist1h3b 8.726367e-36 1.217064 0.976 0.398 1.338363e-31
## Hist1h3f 8.632693e-32 1.211044 0.982 0.537 1.323996e-27
## Cd8b1 1.055272e-30 1.209378 0.997 0.691 1.618470e-26
## Tuba1c 1.177698e-23 1.189895 0.921 0.537 1.806235e-19
## [1] "DE 6 vs 6"
## [1] "DE 6 vs 7"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ikzf2 7.796661e-46 1.8686991 0.976 0.434 1.195774e-41
## Cd7 3.296253e-32 1.6308115 0.865 0.472 5.055463e-28
## Itga4 5.924989e-38 1.5773608 0.903 0.340 9.087156e-34
## Fcer1g 7.618570e-23 1.5209581 0.632 0.164 1.168460e-18
## Cd160 6.149993e-20 1.1079903 0.757 0.340 9.432245e-16
## Anxa2 8.488528e-23 1.0686584 0.760 0.358 1.301886e-18
## Klra6 1.756487e-14 0.9825647 0.726 0.428 2.693925e-10
## Hist1h1e 4.047986e-14 0.9771019 0.736 0.453 6.208396e-10
## Klhdc2 1.073112e-18 0.8728214 0.674 0.264 1.645831e-14
## Ptms 4.565169e-17 0.8194654 0.444 0.057 7.001599e-13
## Prex1 1.641506e-14 0.8059230 0.681 0.377 2.517578e-10
## Lrmp 1.645566e-15 0.7474166 0.573 0.214 2.523804e-11
## Id3 9.207937e-11 0.7203153 0.708 0.447 1.412221e-06
## Cldnd1 6.228243e-10 0.6766192 0.587 0.321 9.552256e-06
## Trat1 4.695210e-13 0.6609418 0.365 0.057 7.201043e-09
## Tsc22d1 4.325270e-12 0.6271198 0.299 0.025 6.633667e-08
## Trgv2 2.499525e-09 0.5245490 0.340 0.088 3.833521e-05
## Ifit2 1.198887e-13 -0.5095377 0.073 0.346 1.838733e-09
## Parp9 5.090338e-12 -0.5114450 0.156 0.440 7.807051e-08
## Sp110 3.792314e-10 -0.5117500 0.396 0.704 5.816271e-06
## Psmb9 1.625894e-10 -0.5224401 0.601 0.912 2.493633e-06
## Ccr7 6.549308e-13 -0.5266524 0.132 0.428 1.004467e-08
## Tapbp 5.701755e-10 -0.5331701 0.493 0.780 8.744782e-06
## Gbp6 2.754332e-13 -0.5361870 0.115 0.409 4.224319e-09
## Ifit3b 4.588582e-21 -0.5400974 0.003 0.289 7.037508e-17
## BE692007 3.813351e-15 -0.5568945 0.156 0.516 5.848536e-11
## Gbp2 1.615935e-13 -0.5574818 0.083 0.365 2.478359e-09
## Ctss 1.974951e-12 -0.5663327 0.264 0.579 3.028983e-08
## Psmb10 3.954614e-13 -0.5663649 0.639 0.912 6.065192e-09
## Daxx 8.217898e-12 -0.5703286 0.167 0.447 1.260379e-07
## [1] "DE 6 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Ikzf2 4.188082e-34 1.6343922 0.976 0.504 6.423262e-30
## Fcer1g 1.367973e-17 1.5112614 0.632 0.211 2.098059e-13
## Cd7 7.368982e-24 1.3979466 0.865 0.463 1.130181e-19
## Pnrc1 9.378148e-24 1.1936508 0.865 0.585 1.438327e-19
## Itga4 6.193819e-25 1.1828260 0.903 0.374 9.499461e-21
## Fos 1.027875e-11 1.0755967 0.778 0.463 1.576452e-07
## Junb 7.883835e-17 1.0326415 0.938 0.602 1.209144e-12
## Ifngr1 8.843126e-16 0.9735928 0.740 0.431 1.356270e-11
## Bcl2 1.645719e-15 0.9720336 0.837 0.585 2.524040e-11
## Smad7 1.132874e-15 0.9658356 0.799 0.528 1.737488e-11
## Clec2d 3.469116e-18 0.9640156 0.868 0.593 5.320584e-14
## Ripor2 1.418723e-17 0.9316846 0.788 0.447 2.175896e-13
## Il7r 9.756993e-10 0.8916042 0.760 0.496 1.496430e-05
## Gimap1 4.930631e-17 0.8462585 0.875 0.593 7.562108e-13
## Cd160 3.019957e-10 0.7939843 0.757 0.496 4.631708e-06
## Samhd1 2.223151e-12 0.7861725 0.646 0.333 3.409646e-08
## Zfp36l1 1.985855e-10 0.7785882 0.743 0.480 3.045706e-06
## Ube2h 4.364370e-11 0.7683649 0.618 0.358 6.693635e-07
## Trbc1 2.161814e-06 0.7656981 0.819 0.545 3.315574e-02
## Prex1 3.617807e-12 0.7650163 0.681 0.350 5.548630e-08
## Gm26740 1.836552e-11 0.7489206 0.604 0.285 2.816719e-07
## Arhgap45 3.443454e-15 0.7469208 0.830 0.569 5.281225e-11
## Cd69 1.535269e-11 0.7458636 0.892 0.626 2.354643e-07
## Rgs1 2.553391e-08 0.7405994 0.490 0.211 3.916136e-04
## Neat1 9.731560e-10 0.7350787 0.771 0.512 1.492529e-05
## Klhdc2 3.305382e-11 0.7173509 0.674 0.366 5.069465e-07
## Tecpr1 2.546517e-11 0.6975960 0.538 0.203 3.905592e-07
## Gpsm3 1.775031e-12 0.6867117 0.729 0.415 2.722365e-08
## Btg2 1.090388e-09 0.6545715 0.812 0.561 1.672329e-05
## Clk1 4.633083e-09 0.6532611 0.684 0.398 7.105759e-05
## [1] "DE 7 vs 7"
## [1] "DE 7 vs 8"
## p_val avg_log2FC pct.1 pct.2 p_val_adj
## Isg15 6.208052e-43 2.5392289 0.950 0.146 9.521289e-39
## Ifi27l2a 1.991573e-14 2.0720160 0.786 0.520 3.054475e-10
## Ifit1 4.905300e-32 1.9860480 0.736 0.008 7.523259e-28
## Ifit3 3.928256e-30 1.7502613 0.736 0.041 6.024766e-26
## Bst2 1.511623e-24 1.6657653 0.868 0.463 2.318377e-20
## Slfn5 7.176465e-23 1.6496892 0.585 0.016 1.100654e-18
## Ifi203 7.307105e-32 1.5398769 0.981 0.724 1.120691e-27
## Samhd1 5.161861e-22 1.5203149 0.818 0.333 7.916747e-18
## Ifi209 2.914382e-26 1.4197085 0.849 0.293 4.469788e-22
## Zbp1 1.481473e-22 1.4090707 0.774 0.285 2.272136e-18
## Plac8 1.891549e-11 1.3688673 0.742 0.455 2.901068e-07
## Slfn1 2.787809e-23 1.3236955 0.774 0.220 4.275663e-19
## Stat1 5.226774e-21 1.2506368 0.862 0.480 8.016303e-17
## Ifi206 4.062605e-23 1.2416623 0.818 0.333 6.230818e-19
## Trim30a 6.965177e-23 1.2229575 0.824 0.333 1.068249e-18
## Usp18 1.402286e-21 1.2216488 0.654 0.106 2.150685e-17
## Ifi208 4.179493e-20 1.1889074 0.767 0.317 6.410088e-16
## Gbp7 1.830062e-16 1.1638632 0.698 0.276 2.806766e-12
## Rnf213 5.631568e-17 1.1335696 0.742 0.382 8.637135e-13
## Ccnd2 8.859117e-19 1.1177519 0.956 0.610 1.358723e-14
## Igtp 1.860592e-18 1.1101762 0.667 0.163 2.853591e-14
## Irf7 1.270689e-17 1.0865549 0.692 0.236 1.948856e-13
## Ifi47 4.897306e-18 1.0503957 0.843 0.561 7.510998e-14
## Slfn8 9.535485e-16 1.0259325 0.654 0.244 1.462457e-11
## Parp14 3.050374e-18 0.9887126 0.736 0.228 4.678358e-14
## Isg20 1.576346e-15 0.9767302 0.434 0.016 2.417643e-11
## Phf11b 4.042554e-12 0.9762821 0.616 0.268 6.200065e-08
## Junb 5.715892e-15 0.9707792 0.962 0.602 8.766463e-11
## Ifi214 2.695727e-12 0.9571335 0.591 0.236 4.134436e-08
## Xaf1 1.188264e-19 0.9329440 0.736 0.220 1.822440e-15
## [1] "DE 8 vs 8"5 Classify cells as G2/M, S, or alternatively G1
5.1 Visualization
6 Creat metadata
6.1 Visualization Cell cycle phase by cluster
6.2 Visualization population by cluster
